ArticleBiophysical journal2000
The probability of quantal secretion near a single calcium channel of an active zone.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 51 citations in OpenAlex.
- Mechanosensitive potassium channels in neurons projecting cardiac axons of the nodose ganglion in rats.Frontiers in physiology · 2025Article
- The Architecture of the Presynaptic Release Site.Advances in neurobiology · 2023Article
- Computational modeling predicts ephemeral acidic microdomains in the glutamatergic synaptic cleft.Biophysical journal · 2021Article
- Transmitter release site organization can predict synaptic function at the neuromuscular junction.Journal of neurophysiology · 2018Article
- An excess-calcium-binding-site model predicts neurotransmitter release at the neuromuscular junction.Biophysical journal · 2013Article
- Effects of calretinin on Ca2+ signals in cerebellar granule cells: implications of cooperative Ca2+ binding.Cerebellum (London, England) · 2012Article
- Role of calcium and mitochondria in MeHg-mediated cytotoxicity.Journal of biomedicine & biotechnology · 2012Review
- From the stochasticity of molecular processes to the variability of synaptic transmission.Nature reviews. Neuroscience · 2011Review
- Synaptic ribbon enables temporal precision of hair cell afferent synapse by increasing the number of readily releasable vesicles: a modeling study.Journal of neurophysiology · 2008Article
- Modeling of quantal neurotransmitter release kinetics in the presence of fixed and mobile calcium buffers.Journal of computational neuroscience · 2008Article
- Mechanisms of target-cell specific short-term plasticity at Schaffer collateral synapses onto interneurones versus pyramidal cells in juvenile rats.The Journal of physiology · 2005Article
- Consequences of molecular-level Ca2+ channel and synaptic vesicle colocalization for the Ca2+ microdomain and neurotransmitter exocytosis: a monte carlo study.Biophysical journal · 2004Article
- The facilitated probability of quantal secretion within an array of calcium channels of an active zone at the amphibian neuromuscular junction.Biophysical journal · 2004Article
- Synaptic vesicles: test for a role in presynaptic calcium regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Formation and function of synapses with respect to Schwann cells at the end of motor nerve terminal branches on mature amphibian (Bufo marinus) muscle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- The probability of quantal secretion within an array of calcium channels of an active zone.Biophysical journal · 2000Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A Monte Carlo analysis has been made of calcium dynamics and quantal secretion at microdomains in which the calcium reaches very high concentrations over distances of <50 nm from a channel and for which calcium dynamics are dominated by diffusion. The kinetics of calcium ions in microdomains due to either the spontaneous or evoked opening of a calcium channel, both of which are stochastic events, are described in the presence of endogenous fixed and mobile buffers. Fluctuations in the number of calcium ions within 50 nm of a channel are considerable, with the standard deviation about half the mean. Within 10 nm of a channel these numbers of ions can give rise to calcium concentrations of the order of 100 microM. The temporal changes in free calcium and calcium bound to different affinity indicators in the volume of an entire varicosity or bouton following the opening of a single channel are also determined. A Monte Carlo analysis is also presented of how the dynamics of calcium ions at active zones, after the arrival of an action potential and the stochastic opening of a calcium channel, determine the probability of exocytosis from docked vesicles near the channel. The synaptic vesicles in active zones are found docked in a complex with their calcium-sensor associated proteins and a voltage-sensitive calcium channel, forming a secretory unit. The probability of quantal secretion from an isolated secretory unit has been determined for different distances of an open calcium channel from the calcium sensor within an individual unit: a threefold decrease in the probability of secretion of a quantum occurs with a doubling of the distance from 25 to 50 nm. The Monte Carlo analysis also shows that the probability of secretion of a quantum is most sensitive to the size of the single-channel current compared with its sensitivity to either the binding rates of the sites on the calcium-sensor protein or to the number of these sites that must bind a calcium ion to trigger exocytosis of a vesicle.
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