ArticleOncogene2000
A murine ATFa-associated factor with transcriptional repressing activity.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis.Nature communications · 2025Article
- Targeting the Tumor Epigenetic Regulator SETDB1 for Tumor Therapy.Current cancer drug targets · 2025Review
- Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells.Nature communications · 2023Article
- Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation.Epigenetics & chromatin · 2014Article
- The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence.PloS one · 2013Article
- Article
- Inheritance and memory of stress-induced epigenome change: roles played by the ATF-2 family of transcription factors.Genes to cells : devoted to molecular & cellular mechanisms · 2012Review
- The Roles of the Methyl-CpG Binding Proteins in Cancer.Genes & cancer · 2011Article
- A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity.PloS one · 2011Article
- Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.The EMBO journal · 2010Article
- Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity.Nucleic acids research · 2007Article
- PSM2, a novel protein similar to MCAF2, is involved in the mouse embryonic and adult male gonad development.Molecular biology reports · 2006Article
- Reduction of spermatogenesis but not fertility in Creb3l4-deficient mice.Molecular and cellular biology · 2005Article
- Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.The Biochemical journal · 2003Article
- MCAF mediates MBD1-dependent transcriptional repression.Molecular and cellular biology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ATFa proteins, which are members of the CREB/ATF family of transcription factors, have previously been shown to interact with the adenovirus E1a oncoprotein and to mediate its transcriptional activity; they heterodimerize with Jun, Fos or related transcription factors, possibly altering their DNA-binding specificity; they also stably bind JNK2, a stress-induced protein kinase. Here we report the identification and characterization of a novel protein isolated in a yeast two-hybrid screen using the N-terminal half of ATFa as a bait. This 1306-residue protein (mAM, for mouse ATFa-associated Modulator) is rather acidic (pHi 4.5) and contains high proportions of Ser/Thr (21%) and Pro (11%) residues. It colocalizes and interacts with ATFa in mammalian cells, contains a bipartite nuclear localization signal and possesses an ATPase activity. Transfection experiments show that mAM is able to downregulate transcriptional activity, in an ATPase-independent manner. Our results indicate that mAM interacts with several components of the basal transcription machinery (TFIIE and TFIIH), including RNAPII itself. Together, these findings suggest that mAM may be involved in the fine-tuning of ATFa-regulated gene expression, by interfering with the assembly or stability of specific preinitiation transcription complexes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.