ArticleJournal of virology2000
Induction of cellular genes is mediated by the Bel1 transactivator in foamy virus-infected human cells.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- PREB inhibits the replication of prototype foamy virus by affecting its transcription.Virology journal · 2023Article
- Modulation of viral replication, apoptosis and antiviral response by induction and mutual regulation of EGR and AP-1 family genes during coronavirus infection.Emerging microbes & infections · 2022Article
- Article
- SGK1, a Serine/Threonine Kinase, Inhibits Prototype Foamy Virus Replication.Microbiology spectrum · 2022Article
- The Regulation of Prototype Foamy Virus 5'Long Terminal Repeats and Internal Promoter by Endogenous Transcription Factors.Intervirology · 2022Article
- Examining the role of EGR1 during viral infections.Frontiers in microbiology · 2022Review
- Egr-1 regulates RTA transcription through a cooperative involvement of transcriptional regulators.Oncotarget · 2017Article
- Mutagenesis of N-terminal residues of feline foamy virus Gag reveals entirely distinct functions during capsid formation, particle assembly, Gag processing and budding.Retrovirology · 2016Article
- Non-simian foamy viruses: molecular virology, tropism and prevalence and zoonotic/interspecies transmission.Viruses · 2013Review
- N-terminally myristoylated feline foamy virus Gag allows Env-independent budding of sub-viral particles.Viruses · 2011Article
- Lytic HSV-1 infection induces the multifunctional transcription factor Early Growth Response-1 (EGR-1) in rabbit corneal cells.Virology journal · 2011Article
- Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice.The Journal of clinical investigation · 2008Article
- Early growth response-1 protein is induced by JC virus infection and binds and regulates the JC virus promoter.Virology · 2008Article
- Construction and characterization of efficient, stable and safe replication-deficient foamy virus vectors.Gene therapy · 2007Article
- Induction of transcription factor Egr-1 gene expression in astrocytoma cells by Murine coronavirus infection.Virology · 2006Article
- Human foamy virus bel1 sequence in patients with autoimmune rheumatic diseases.Clinical rheumatology · 2006Article
- Furin-mediated cleavage of the feline foamy virus Env leader protein.Journal of virology · 2004Article
- Coactivators p300 and PCAF physically and functionally interact with the foamy viral trans-activator.BMC molecular biology · 2004Article
- Application of chimeric feline foamy virus-based retroviral vectors for the induction of antiviral immunity in cats.Journal of virology · 2003Article
- Global impact of influenza virus on cellular pathways is mediated by both replication-dependent and -independent events.Journal of virology · 2001Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To gain insight into human foamy virus (HFV; also called spumaretrovirus)-induced alterations of cellular genes, the expression profiles of defined genes in HFV-infected primary human cells were analyzed by cDNA array assays. Several distinct cellular genes activated by HFV infection were identified; the identities of the cellular genes were confirmed by RNA blot analyses. Compared with mock-infected controls, the concentrations of cellular Kip2, Egr-1, COUP-TF1, insulin-like growth factor II (IGF-II), and EphB3 mRNAs were significantly increased in HFV-infected cells and showed a gene-specific and time-dependent induction. Immunoblot analyses with antibodies against some of the cellular gene products revealed increased levels of the corresponding proteins. To investigate mechanisms of HFV-induced alterations in cellular gene expression, the capacity of known HFV genes to increase expression of defined cellular genes was analyzed by transient expression experiments. Plasmids that encode the HFV Bel1 transcriptional transactivator were necessary and sufficient to strongly increase expression of p57Kip2, IGF-II, and EphB3 genes in 293T cells. Potential mechanisms and consequences of activation of cellular genes during HFV infection and Bel1 transactivation of the Kip2 gene are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.