ArticleAmerican journal of human genetics2000
Evidence of linkage of familial hypoalphalipoproteinemia to a novel locus on chromosome 11q23.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 52 citations in OpenAlex.
- Znf202 affects high density lipoprotein cholesterol levels and promotes hepatosteatosis in hyperlipidemic mice.PloS one · 2013Article
- Population-Based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels.Frontiers in genetics · 2012Article
- Genetic causes of high and low serum HDL-cholesterol.Journal of lipid research · 2010Review
- A genome-wide linkage scan identifies multiple quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI.Journal of lipid research · 2010Article
- Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders.Molecular autism · 2010Article
- Genomic susceptibility Loci for brain atrophy, ventricular volume, and leukoaraiosis in hypertensive sibships.Archives of neurology · 2009Article
- Human genetics of variation in high-density lipoprotein cholesterol.Current atherosclerosis reports · 2006Review
- Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia.Human genetics · 2005Article
- Confirmation of the HPCX prostate cancer predisposition locus in large Utah prostate cancer pedigrees.Human genetics · 2005Article
- Do DNA sequence variants in ABCA1 contribute to HDL cholesterol levels in the general population?The Journal of clinical investigation · 2004Review
- Article
- Predisposition locus for major depression at chromosome 12q22-12q23.2.American journal of human genetics · 2003Article
- Monogenic dyslipidemias: window on determinants of plasma lipoprotein metabolism.American journal of human genetics · 2001Review
- All in the family: the BTB/POZ, KRAB, and SCAN domains.Molecular and cellular biology · 2001Review
- Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children.Genetics and molecular biologyArticle
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary heart disease (CHD) accounts for half of the 1 million deaths annually ascribed to cardiovascular disease and for almost all of the 1.5 million acute myocardial infarctions. Within families affected by early and apparently heritable CHD, dyslipidemias have a much higher prevalence than in the general population; 20%-30% of early familial CHD has been ascribed to primary hypoalphalipoproteinemia (low HDL-C). This study assesses the evidence for linkage of low HDL-C to chromosomal region 11q23 in 105 large Utah pedigrees ascertained with closely related clusters of early CHD and expanded on the basis of dyslipidemia. Linkage analysis was performed by use of 22 STRP markers in a 55-cM region of chromosome 11. Two-point analysis based on a general, dominant-phenotype model yielded LODs of 2.9 for full pedigrees and 3.5 for 167 four-generation split pedigrees. To define a localization region, model optimization was performed using the heterogeneity, multipoint LOD score (mpHLOD). This linkage defines a region on 11q23.3 that is approximately 10 cM distal to-and apparently distinct from-the ApoAI/CIII/AIV gene cluster and thus represents a putative novel localization for the low HDL-C phenotype.
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