ArticleThe EMBO journal2000
The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed, 173 citations in OpenAlex.
- Biotinylation-dependent near-neighbor analysis for identification of septation regulators inbioRxiv : the preprint server for biology · 2026Article
- Inducible gene deletion reveals essentiality of protein kinases and a septation initiation network in Candida albicans.PLoS genetics · 2026Article
- Characterization of temperature-sensitive alleles of the septation initiation network protein Mob1 inmicroPublication biology · 2025Article
- Transient PP2A SIP complex localization to mitotic SPBs for SIN inhibition is mediated solely by the Csc1 FHA domain.Molecular biology of the cell · 2024Article
- MOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation inmSphere · 2024Article
- Characterization of temperature-sensitive alleles ofmicroPublication biology · 2024Article
- A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network.Journal of cell science · 2024Article
- Design principles of Cdr2 node patterns in fission yeast cells.Molecular biology of the cell · 2023Article
- Design principles of Cdr2 node patterns in fission yeast cells.bioRxiv : the preprint server for biology · 2023Article
- Tetracarboxylic acid transporter regulates growth, conidiation, and carbon utilization in Metarhizium acridum.Applied microbiology and biotechnology · 2023Article
- Article
- Uncoupling of Mitosis and Cytokinesis Upon a Prolonged Arrest in Metaphase Is Influenced by Protein Phosphatases and Mitotic Transcription in Fission Yeast.Frontiers in cell and developmental biology · 2022Article
- Moonlighting at the Poles: Non-Canonical Functions of Centrosomes.Frontiers in cell and developmental biology · 2022Review
- Review
- Article
- A component of the septation initiation network complex, AaSepM, is involved in multiple cellulose-responsive signaling pathways in Aspergillus aculeatus.Applied microbiology and biotechnology · 2021Article
- MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis.Biology · 2020Review
- A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis inGenetics · 2020Article
- Fission yeast type 2 node proteins Blt1p and Gef2p cooperate to ensure timely completion of cytokinesis.BMC molecular and cell biology · 2019Article
- Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Coordination of mitosis and cytokinesis is crucial for ensuring proper chromosome segregation and genomic stability. In Schizosaccharomyces pombe, the sid genes (cdc7, cdc11, cdc14, spg1, sid1, sid2 and sid4) define a signaling pathway that regulates septation and cytokinesis. Here we describe the characterization of a novel protein kinase, Sid1p. Sid1p localizes asymmetrically to one spindle pole body (SPB) in anaphase. Sid1p localization is maintained during medial ring constriction and septum synthesis and disappears prior to cell separation. Additionally, we found that Cdc14p is in a complex with Sid1p. Epistasis analysis places Sid1p-Cdc14p downstream of Spg1p-Cdc7p but upstream of Sid2p. Finally, we show that cyclin proteolysis during mitosis is unaffected by inactivating the sid pathway; in fact, loss of Cdc2-cyclin activity promotes Sid1p-Cdc14p association with the SPB, possibly providing a mechanism that couples cytokinesis with mitotic exit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.