ArticleCell growth & differentiation : the molecular biology journal of the American Association for Cancer Research2000
An in vivo function for the transforming Myc protein: elicitation of the angiogenic phenotype.
Article in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 80 citations in OpenAlex.
- Transient MYC Mimicking the Exercise Response Orchestrates Multifaceted Skeletal Muscle Adaptations.bioRxiv : the preprint server for biology · 2026Article
- Myc family proteins: Molecular drivers of tumorigenesis and resistance in neuroendocrine tumors.Biochimica et biophysica acta. Reviews on cancer · 2025Review
- RABL6A Promotes Pancreatic Neuroendocrine Tumor Angiogenesis and Progression In Vivo.Biomedicines · 2021Article
- A Combination of an Antimitotic and a Bromodomain 4 Inhibitor Synergistically Inhibits the Metastatic MDA-MB-231 Breast Cancer Cell Line.BioMed research international · 2019Article
- Management of Patients with MYC-Altered Lymphomas.Current hematologic malignancy reports · 2016Review
- Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells.Oncogene · 2015Article
- Site-specific programming of the host epithelial transcriptome by the gut microbiota.Genome biology · 2015Article
- Article
- Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours.Clinical sarcoma research · 2014Article
- c-MYC-regulated miR-23a/24-2/27a cluster promotes mammary carcinoma cell invasion and hepatic metastasis by targeting Sprouty2.The Journal of biological chemistry · 2013Article
- In vivo imaging-based mathematical modeling techniques that enhance the understanding of oncogene addiction in relation to tumor growth.Computational and mathematical methods in medicine · 2013Article
- Tumor microenvironment: becoming sick of Myc.Cellular and molecular life sciences : CMLS · 2012Review
- Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.The Journal of biological chemistry · 2012Article
- Differential expression of microRNAs in different disease states.Circulation research · 2012Review
- The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.Cancer research · 2010Article
- Myc: the beauty and the beast.Genes & cancer · 2010Article
- Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.Genes & development · 2006Article
- Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.Nature genetics · 2006Article
- Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.Molecular and cellular biology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The ability of neoplastic cells to recruit blood vasculature is crucial to their survival in the host organism. However, the evidence linking dominant oncogenes to the angiogenic switch remains incomplete. We demonstrate here that Myc, an oncoprotein implicated in many human malignancies, stimulates neovascularization. As an experimental model, we used Rat-1A fibroblasts that form vascular tumors upon transformation by Myc in immunocompromised mice. Our previous work and the use of neutralizing antibodies reveal that in these cells, the angiogenic switch is achieved via down-modulation of thrombospondin-1, a secreted inhibitor of angiogenesis, whereas the levels of vascular endothelial growth factor, a major activator of angiogenesis, remain high and unaffected by Myc. Consistent with this finding, overexpression of Myc confers upon the conditioned media the ability to promote migration of adjacent endothelial cells in vitro and corneal neovascularization in vivo. Furthermore, mobilization of estrogen-dependent Myc in vivo with the appropriate steroid provokes neovascularization of cell implants embedded in Matrigel. These data suggest that Myc is fully competent to trigger the angiogenic switch in vivo and that secondary events may not be required for neovascularization of Myc-induced tumors.
Indexed as
Identifiers
10775037PMC1635548W2134128698What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.