ArticleOncogene2000
GA-binding protein alpha/beta is a critical regulator of the BRCA1 promoter.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- GABPB1 plays a cancer-promoting role in non-small cell lung cancer.Discover oncology · 2024Article
- Vitamin D receptor (VDR) and metabolizing enzymes CYP27B1 and CYP24A1 in breast cancer.Molecular biology reports · 2020Review
- lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter.iScience · 2020Article
- SNPs in lncRNA Regions and Breast Cancer Risk.Frontiers in genetics · 2020Article
- How latent viruses cause breast cancer: An explanation based on the microcompetition model.Bosnian journal of basic medical sciences · 2019Review
- BRCA1 and BRCA2 5' noncoding region variants identified in breast cancer patients alter promoter activity and protein binding.Human mutation · 2018Article
- Non-Coding Variants inCancers · 2018Review
- Article
- The ETS family of oncogenic transcription factors in solid tumours.Nature reviews. Cancer · 2017Review
- Beyond the histone tale: HP1α deregulation in breast cancer epigenetics.Cancer biology & therapy · 2015Review
- Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells.Journal of cancer prevention · 2014Article
- Reversing Platinum Resistance in High-Grade Serous Ovarian Carcinoma: Targeting BRCA and the Homologous Recombination System.Frontiers in oncology · 2014Review
- The dual lives of bidirectional promoters.Biochimica et biophysica acta · 2012Review
- Article
- c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells.BMC cancer · 2011Article
- Abnormal expression of NRF-2α in hepatocellular carcinoma identified with a newly prepared monoclonal antibody against human NRF-2α protein.Molecular biology reports · 2011Article
- Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex.Molecular cancer · 2011Article
- Characterization of a negative transcriptional element in the BRCA1 promoter.Breast cancer research : BCR · 2007Article
- A novel activating function of c-Src and Stat3 on HGF transcription in mammary carcinoma cells.Oncogene · 2006Article
- The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer.Reproductive biology and endocrinology : RB&E · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decreased expression of BRCA1 may play a role in the etiology of sporadic breast cancer. Deletion and point mutant analysis of proximal promoter elements in the BRCA1 1a promoter revealed a 22 bp region which was critical for the expression of the promoter in MCF-7 cells, but had a much reduced effect in T47D cells. The main transcription factor interacting with this site was identified as GABPalpha/beta, and a discrete DNA binding complex was only observed in nuclear extracts from MCF-7 cells. Cotransfection experiments with GABPalpha and beta1 expression vectors produced transactivation of this element in both lines. These results suggest that GABPalpha/beta is a critical activator of BRCA1 expression, and that its activity may differ in human breast cell lines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.