ArticleNucleic acids research2000
Hemicatenanes form upon inhibition of DNA replication.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Topoisomerase II deficiency leads to a postreplicative structural shift in all Saccharomyces cerevisiae chromosomes.Scientific reports · 2021Article
- Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites.Nature communications · 2021Article
- A tri-serine cluster within the topoisomerase IIα-interaction domain of the BLM helicase is required for regulating chromosome breakage in human cells.Human molecular genetics · 2018Article
- A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans.PLoS genetics · 2015Article
- Article
- DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity.The EMBO journal · 2014Article
- TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability.The Journal of cell biology · 2014Article
- Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cdc45 is a critical effector of myc-dependent DNA replication stress.Cell reports · 2013Article
- Friedreich's ataxia-associated GAA repeats induce replication-fork reversal and unusual molecular junctions.Nature structural & molecular biology · 2013Article
- Complexes between two GAA Repeats within DNA introduced into Cos-1 cells.Mobile genetic elements · 2012Article
- RNase-dependent discontinuities associated with the crossovers of spontaneously formed joint DNA molecules in Physarum polycephalum.Chromosoma · 2010Article
- Evidence that a RecQ helicase slows senescence by resolving recombining telomeres.PLoS biology · 2007Article
- Sister chromatid junctions in the hyperthermophilic archaeon Sulfolobus solfataricus.The EMBO journal · 2007Article
- Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase.Genes & development · 2005Article
- Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage.Molecular and cellular biology · 2004Article
- Rad52-independent accumulation of joint circular minichromosomes during S phase in Saccharomyces cerevisiae.Molecular and cellular biology · 2003Article
- Structural analysis of hemicatenated DNA loops.BMC structural biology · 2002Article
- Visualization of hemiknot DNA structure with an atomic force microscope.Nucleic acids research · 2002Article
- Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility.Nucleic acids research · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmid DNA incubated in interphase Xenopus egg extracts is normally assembled into chromatin and then into synthetic nuclei which undergo one round of regulated replication. During a study of restriction endonuclease cut plasmid replication intermediates (RIs) by the Brewer-Fangman 2D gel electrophoresis technique, we have observed the formation of a strong spike of X-shaped DNA molecules in extracts that otherwise yield very little or no RIs. Formation of these joint molecules is also efficiently induced in replication-competent extracts upon inhibition of replication fork progression by aphidicolin. Although their electrophoretic properties are quite similar to those of Holliday junctions, 2D gels of doubly cut plasmids show that these junctions can link two plasmid molecules at any pair of DNA sequences, with no regard for sequence homology at the branch points. Neutral-neutral-alkaline 3D gels show that the junctions only contain single strands of parental size and no recombinant strands. A hemicatenane, in which one strand of a duplex is wound around one strand of another duplex, is the most likely structure to account for these observations. The mechanism of formation of these novel joint DNA molecules and their biological implications are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.