ReviewNucleic acids research2000
Spatial organization of RNA polymerase II transcription in the nucleus.
Review in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Molecular grammars of predicted intrinsically disordered regions that span the human proteome.Cell · 2026Article
- Introns: the "dark matter" of the eukaryotic genome.Frontiers in genetics · 2023Review
- Ex vivo visualization of RNA polymerase III-specific gene activity with electron microscopy.Communications biology · 2021Article
- Cofilin-1 Is a Mechanosensitive Regulator of Transcription.Frontiers in cell and developmental biology · 2020Article
- PIN1 is a new therapeutic target of craniosynostosis.Human molecular genetics · 2018Article
- Diaphanous formin mDia2 regulates CENP-A levels at centromeres.The Journal of cell biology · 2016Article
- Epigenetic silencing of the XAF1 gene is mediated by the loss of CTCF binding.Scientific reports · 2015Article
- Murine leukemia virus RNA dimerization is coupled to transcription and splicing processes.Retrovirology · 2010Article
- Evidence for transcriptional activity in the syncytiotrophoblast of the human placenta.Placenta · 2009Article
- Anchoring the genome.Genome biology · 2008Review
- Characterization of a natural heterodimer between MLV genomic RNA and the SD' retroelement generated by alternative splicing.RNA (New York, N.Y.) · 2007Article
- Active chromatin hub of the mouse alpha-globin locus forms in a transcription factory of clustered housekeeping genes.Molecular and cellular biology · 2006Article
- Gene activation and deactivation related changes in the three-dimensional structure of chromatin.Chromosoma · 2005Review
- Actively transcribing RNA polymerase II concentrates on spliced leader genes in the nucleus of Trypanosoma cruzi.Eukaryotic cell · 2005Article
- Novel DNA-binding properties of the RNA-binding protein TIAR.Nucleic acids research · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotic cells, mRNA synthesis is carried out by large, multifunctional complexes that are also involved in coordinating transcription with other nuclear processes. This survey focuses on the distribution and structural arrangement of these complexes within the nucleus, in relationship with the discrete positioning of particular chromosomal loci. To better understand the link between the spatial organization of the nucleus and the regulation of gene expression, it is necessary to combine information from biochemical studies with results from microscopic observations of preserved nuclear structures. Recent experimental approaches have made this possible. The subnuclear locations of specific chromosome loci, RNA transcripts, RNA polymerases, and transcription and pre-mRNA-processing factors can now be observed with computer-assisted microscopy and specific molecular probes. The results indicate that RNA polymerase II (RNAPII) transcription takes place at discrete sites scattered throughout the nucleoplasm, and that these sites are also the locations of pre-mRNA processing. Transcribing polymerases appear to be grouped into clusters at each transcription site. Cell cycle-dependent zones of transcription and processing factors have been identified, and certain subnuclear domains appear specialized for expression or silencing of particular genes. The arrangement of transcription in the nucleus is dynamic and depends on its transcriptional activity, with the RNAPII itself playing a central role in marshalling the large complexes involved in gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.