ReviewJournal of abnormal child psychology2000
Genetic studies of autism: from the 1970s into the millennium.
Review in Journal of abnormal child psychology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Autism spectrum disorder and schizophrenia: An updated conceptual review.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Children with autistic spectrum disorders. I: comparison of placebo and single dose of human synthetic secretin.Archives of disease in childhood · 2003Trial
- Digestive Neurobiology in Autism: From Enteric and Central Nervous System Interactions to Shared Genetic Pathways.International journal of molecular sciences · 2025Review
- Review
- A sensory signature of unaffected biological parents predicts the risk of autism in their offspring.Psychiatry and clinical neurosciences · 2024Article
- Maternal dietary intake of fish and child neurodevelopment at 3 years: a nationwide birth cohort-The Japan Environment and Children's Study.Frontiers in public health · 2023Article
- Genetic Advances in Autism.Journal of autism and developmental disorders · 2021Review
- The DSM-5 introduction of the Social (Pragmatic) Communication Disorder as a new mental disorder: a philosophical review.History and philosophy of the life sciences · 2021Review
- Autism sensory dysfunction in an evolutionarily conserved system.Proceedings. Biological sciences · 2018Article
- Comprehensive literature data-mining analysis reveals a broad genetic network functionally associated with autism spectrum disorder.International journal of molecular medicine · 2018Article
- Resting-state alpha power is selectively associated with autistic traits reflecting behavioral rigidity.Scientific reports · 2018Article
- Autism Spectrum Traits Linked with Reduced Performance on Self-Report Behavioural Measures of Cognitive Flexibility.Journal of autism and developmental disorders · 2018Article
- The maternal body as environment in autism science.Social studies of science · 2016Article
- The association between familial ASD diagnosis, autism symptomatology and developmental functioning in young children.European child & adolescent psychiatry · 2016Article
- Social (Pragmatic) Communication Disorder and Its Relation to the Autism Spectrum: Dilemmas Arising From the DSM-5 Classification.Journal of autism and developmental disorders · 2016Review
- Enhanced brain signal variability in children with autism spectrum disorder during early childhood.Human brain mapping · 2016Article
- Theory of Mind Indexes the Broader Autism Phenotype in Siblings of Children with Autism at School Age.Autism research and treatment · 2016Article
- Broad autism phenotype features of Chinese parents with autistic children and their associations with severity of social impairment in probands.BMC psychiatry · 2015Article
- Association of NCAM1 polymorphisms with autism and parental age at conception in a Chinese Han population.Genetic testing and molecular biomarkers · 2014Article
- Variations analysis of NLGN3 and NLGN4X gene in Chinese autism patients.Molecular biology reports · 2014Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reviewers in the 1960s and early 1970s were skeptical about any substantial role for genetic factors in the etiology of autism. A realization that the 2% rate of autism in siblings (as estimated at that time) was far above the general population base rate, and that this suggested a possible high genetic liability, led to the first small-scale twin study of autism. The replicated evidence from both twin and family studies undertaken in the 1970s and 1980s indicated both strong genetic influences and the likelihood that they applied to a phenotype that was much broader than the traditional diagnostic category of autism. Medical and chromosomal findings also indicated genetic heterogeneity. Advances in molecular genetics led to genome-wide scans of affected relative pair samples with a positive log of the odds to base 10 score for a location on chromosome 7. The major remaining research challenges and the likely clinical benefits that should derive from genetic research are considered in relation to both current knowledge and that anticipated to emerge from research over the next decade.
Indexed as
Identifiers
10772346What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.