ArticleThe Journal of experimental medicine2000
Entry of B cell receptor into signaling domains is inhibited in tolerant B cells.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 86 citations in OpenAlex.
- NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance.Communications biology · 2022Article
- Characterization of interactions within the Igα/Igβ transmembrane domains of the human B-cell receptor provides insights into receptor assembly.The Journal of biological chemistry · 2022Article
- Mechanisms of central tolerance for B cells.Nature reviews. Immunology · 2017Review
- Different associations of CD45 isoforms with STAT3, PKC and ERK regulate IL-6-induced proliferation in myeloma.PloS one · 2015Article
- Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis.The Journal of clinical investigation · 2013Article
- Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile.Journal of autoimmunity · 2012Article
- Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.Immunity · 2009Article
- Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors.The Journal of experimental medicine · 2009Article
- Bispecific anti-CD20/22 antibodies inhibit B-cell lymphoma proliferation by a unique mechanism of action.Blood · 2008Article
- Understanding B-cell tolerance through the use of immunoglobulin transgenic models.Immunologic research · 2008Review
- B-cell anergy: from transgenic models to naturally occurring anergic B cells?Nature reviews. Immunology · 2007Review
- Induction of cell signaling events by the cholera toxin B subunit in antigen-presenting cells.Infection and immunity · 2007Article
- Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy.The Journal of experimental medicine · 2006Article
- A B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells.The Journal of experimental medicine · 2004Article
- Models of signal transduction through the B-cell antigen receptor.Immunology · 2003Review
- The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction.The EMBO journal · 2003Article
- Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling.The EMBO journal · 2002Article
- Transmodulation of BCR signaling by transduction-incompetent antigen receptors: implications for impaired signaling in anergic B cells.Journal of immunology (Baltimore, Md. : 1950) · 2002Article
- Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis.The Journal of experimental medicine · 2001Article
- Ligand-dependent and -independent processes in B-cell-receptor-mediated signaling.Springer seminars in immunopathology · 2001Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Signal transduction through the B cell antigen receptor (BCR) is altered in B cells that express a receptor that recognizes self-antigen. To understand the molecular basis for the change in signaling in autoreactive B cells, a transgenic model was used to isolate a homogeneous population of tolerant B lymphocytes. These cells were compared with a similar population of naive B lymphocytes. We show that the BCR from naive B cells enters a detergent-insoluble domain of the cell within 6 s after antigen binding, before a detectable increase in BCR phosphorylation. This fraction appears to be important for signaling because it is enriched for lyn kinase but lacks CD45 tyrosine phosphatase and because the BCR that moves into this domain becomes more highly phosphorylated. Partitioning of the BCR into this fraction is unaffected by src family kinase inhibition. Tolerant B cells do not efficiently partition the BCR into the detergent-insoluble domain, providing an explanation for their reduced tyrosine kinase activation and calcium flux in response to antigen. These results identify an early, regulated step in antigen receptor signaling and self-tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.