ArticleThe Journal of experimental medicine2000
Evidence for class-specific factors in immunoglobulin isotype switching.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Differential regulation of immunoglobulin class switch recombination by the tumor suppressor p53.Scientific reports · 2026Article
- [Endogenous neddylation in B cells regulates immune responses in mice].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Article
- Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination.Nature communications · 2015Article
- Expression of IgA class switching gene in tonsillar mononuclear cells in patients with IgA nephropathy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Switch region identity plays an important role in Ig class switch recombination.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching.The Journal of experimental medicine · 2008Article
- Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney.Molecular immunology · 2008Article
- Mechanism and regulation of class switch recombination.Annual review of immunology · 2008Review
- Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.European journal of immunology · 2008Article
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- NF-kappa B binds to the immunoglobulin S gamma 3 region in vivo during class switch recombination.European journal of immunology · 2006Article
- Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2006Review
- AID-dependent histone acetylation is detected in immunoglobulin S regions.The Journal of experimental medicine · 2006Article
- Evolution of antibody class switching: identification and transcriptional control of an Inu exon in the duck (Anas platyrhynchos).Developmental and comparative immunology · 2006Article
- Influence of switch region length on immunoglobulin class switch recombination.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor.The Journal of experimental medicine · 2004Article
- Class-switch recombination: after the dawn of AID.Current opinion in immunology · 2003Review
- Two new isotype-specific switching activities detected for Ig class switching.Journal of immunology (Baltimore, Md. : 1950) · 2002Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Immunoglobulin class switch recombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch regions. We have developed a plasmid-based transient transfection assay for SR to test for the presence of transacting switch activities. The plasmids are novel in that they lack a eukaryotic origin of DNA replication. The recombination activity of these switch substrates is restricted to a subset of B cell lines that support isotype switching on their endogenous loci and to mitogen-activated normal splenic B cells. The factors required for extrachromosomal plasmid recombination are constitutively expressed in proliferating splenic B cells and in B cell lines capable of inducibly undergoing immunoglobulin SR on their chromosomal genes. These studies suggest that mitogens that induce switching on the chromosome induce accessibility rather than switch recombinase activity. Finally, we provide evidence for two distinct switching activities which independently mediate mu-->alpha and mu-->gamma3 SR.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.