ArticleAntimicrobial agents and chemotherapy2000
Antibacterial agents and release of periplasmic pertussis toxin from Bordetella pertussis.
Article in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- The Case against Antibiotics and for Anti-Virulence Therapeutics.Microorganisms · 2021Review
- Therapeutic effect of vitamin K1 combined with meropenem on the treatment of pertussis syndrome.Experimental and therapeutic medicine · 2019Article
- Genotypes and phenotypes of Shiga toxin-producing Escherichia coli (STEC) in Abeokuta, Southwestern Nigeria.Infection and drug resistance · 2014Article
- Reduced glutathione is required for pertussis toxin secretion by Bordetella pertussis.Infection and immunity · 2003Article
- DsbA and DsbC are required for secretion of pertussis toxin by Bordetella pertussis.Infection and immunity · 2002Article
- Growth phase influences complement resistance of Bordetella pertussis.Infection and immunity · 2002Article
- Pertussis toxin and lipopolysaccharide influence phagocytosis of Bordetella pertussis by human monocytes.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Pertussis toxin accumulates in the periplasm of Bordetella pertussis prior to secretion, and we examined its fate following treatment with antimicrobial agents. Both antibiotics that inhibit protein synthesis (erythromycin and chloramphenicol), transcription (rifampin), or cell wall biosynthesis (cefoperazone and piperacillin) and magnesium sulfate (which inhibits transcription of pertussis toxin, but not bacterial growth) did not prevent release of preformed toxin. In contrast, agents that affect bacterial membranes, such as polymyxin B, lidocaine, procaine, and ethanol, inhibited release of preformed pertussis toxin. These results suggest new protein synthesis is not required for pertussis toxin secretion, but a functional membrane complex is required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.