ArticleThe Biochemical journal2000
Polyamines directly induce release of cytochrome c from heart mitochondria.
Article in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 75 citations in OpenAlex.
- Polyamine metabolism in ischemia reperfusion injury: common mitochondrial mechanisms and organ-specific differences.Journal of translational medicine · 2026Review
- Polyamine metabolism in cancer: drivers of immune evasion, ferroptosis and therapy resistance.Expert reviews in molecular medicine · 2025Review
- Review
- Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity.Cells · 2022Review
- Diosmetin inhibits apoptosis and activates AMPK-induced autophagy in myocardial damage under hypoxia environment.The Kaohsiung journal of medical sciences · 2022Article
- New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases.Aging and disease · 2021Review
- Prevention of multiple system atrophy using human bone marrow-derived mesenchymal stem cells by reducing polyamine and cholesterol-induced neural damages.Stem cell research & therapy · 2020Article
- Spermine Differentially Refines Plant Defense Responses Against Biotic and Abiotic Stresses.Frontiers in plant science · 2019Review
- Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features.Allergy · 2018Article
- Spermine ameliorates ischemia/reperfusion injury in cardiomyocytes via regulation of autophagy.American journal of translational research · 2016Article
- Quantitative subcellular study of transferrin receptor-targeted doxorubicin and its metabolite in human breast cancer cells.European journal of drug metabolism and pharmacokinetics · 2014Article
- Interaction of poly(ethylenimine)-DNA polyplexes with mitochondria: implications for a mechanism of cytotoxicity.Molecular pharmaceutics · 2011Article
- Perturbation of polyamine catabolism can strongly affect root development and xylem differentiation.Plant physiology · 2011Article
- Polyamines in aging and disease.Aging · 2011Review
- The role of polyamines in protein-dependent hypoxic tolerance of Drosophila.BMC physiology · 2008Article
- Inhibitory effect of DIDS, NPPB, and phloretin on intracellular chloride channels.Pflugers Archiv : European journal of physiology · 2007Article
- Nitric oxide and promotion of cardiac myocyte apoptosis.Molecular and cellular biochemistry · 2004Article
- Characterization of transgenic mice with widespread overexpression of spermine synthase.The Biochemical journal · 2004Article
- Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy.The Biochemical journal · 2001Article
- Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells.The Biochemical journal · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome c release from mitochondria to the cytosol represents a critical step in apoptosis, correlated to the activation of the caspase cascade. In this report, we show that addition of micromolar concentrations of polyamines to isolated rat heart mitochondria induces the release of cytochrome c. Spermine, which is effective at concentrations of 10-100 microM, is more potent than spermidine, whereas putrescine has no effect up to 1 mM. The release of cytochrome c caused by spermine is a rapid, saturable and selective process that is independent of mitochondria damage. Spermine, unlike polylysine, is able to release a discrete amount of cytochrome c from intact, functional mitochondria. The cytochrome c-releasing power of spermine is not affected by cyclosporin A, differently from the effect of permeability transition inducers. In a cardiac cell-free model of apoptosis, the latent caspase activity of cytosolic extracts from cardiomyocytes could be activated by cytochrome c released from spermine-treated heart mitochondria. These data indicate a novel mechanism of cytochrome c release from the mitochondrion, and suggest that prolonged and sustained elevation of polyamines, characteristic of some pathologies such as heart hypertrophy, could be involved in the development of apoptosis.
Indexed as
Identifiers
10769194PMC1221027W2067761408What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.