ReviewThe Biochemical journal2000
Role of lipids in the translocation of proteins across membranes.
Review in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- The aggregation tendencies of the signal peptide regions of prone and not prone to aggregate proteins.Biochemistry and biophysics reports · 2025Article
- The inhibitory potential of three scorpion venom peptides against multidrug-resistantFrontiers in microbiology · 2025Article
- A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs.The Journal of membrane biology · 2024Review
- Increasing the Efficiency of the Accumulation of Recombinant Proteins in Plant Cells: The Role of Transport Signal Peptides.Plants (Basel, Switzerland) · 2022Review
- Binding of SecA ATPase monomers and dimers to lipid vesicles.Biochimica et biophysica acta. Biomembranes · 2020Article
- Dynamic membrane protein topological switching upon changes in phospholipid environment.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mechanisms of integral membrane protein insertion and folding.Journal of molecular biology · 2015Review
- Lipids and topological rules governing membrane protein assembly.Biochimica et biophysica acta · 2014Review
- Fluorescence spectroscopy of soluble E. coli SPase I Δ2-75 reveals conformational changes in response to ligand binding.Proteins · 2014Article
- Article
- A single copy of SecYEG is sufficient for preprotein translocation.The EMBO journal · 2011Article
- Mutual effects of MinD-membrane interaction: II. Domain structure of the membrane enhances MinD binding.Biochimica et biophysica acta · 2008Article
- Functional taxonomy of bacterial hyperstructures.Microbiology and molecular biology reviews : MMBR · 2007Review
- A directed evolution strategy for optimized export of recombinant proteins reveals critical determinants for preprotein discharge.Protein science : a publication of the Protein Society · 2004Article
- Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane?Journal of bacteriology · 2003Article
- Topology of polytopic membrane protein subdomains is dictated by membrane phospholipid composition.The EMBO journal · 2002Article
- Overexpression of yccL (gnsA) and ydfY (gnsB) increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation of Escherichia coli.Journal of bacteriology · 2001Article
- Reconstitution of membrane proteins into giant unilamellar vesicles via peptide-induced fusion.Biophysical journal · 2001Article
- Phosphatidic acid-phosphatidylethanolamine interaction and apocytochrome c translocation across model membranes.The Biochemical journal · 2001Article
- Recognition of preproteins by the isolated TOM complex of mitochondria.The EMBO journal · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The architecture of cells, with various membrane-bound compartments and with the protein synthesizing machinery confined to one location, dictates that many proteins have to be transported through one or more membranes during their biogenesis. A lot of progress has been made on the identification of protein translocation machineries and their sorting signals in various organelles and organisms. Biochemical characterization has revealed the functions of several individual protein components. Interestingly, lipid components were also found to be essential for the correct functioning of these translocases. This led to the idea that there is a very intimate relationship between the lipid and protein components that enables them to fulfil their intriguing task of transporting large biopolymers through a lipid bilayer without leaking their contents. In this review we focus on the Sec translocases in the endoplasmic reticulum and the bacterial inner membrane. We also highlight the interactions of lipids and proteins during the process of translocation and integrate this into a model that enables us to understand the role of membrane lipid composition in translocase function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.