ArticleThe Journal of cell biology2000
The ribosomal RNA processing machinery is recruited to the nucleolar domain before RNA polymerase I during Xenopus laevis development.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- On some structural and evolutionary aspects of rDNA amplification in oogenesis of Trachemys scripta turtles.Cell and tissue research · 2021Article
- The role of transcription in shaping the spatial organization of the genome.Nature reviews. Molecular cell biology · 2019Review
- Article
- Nucleation by rRNA Dictates the Precision of Nucleolus Assembly.Current biology : CB · 2016Article
- Humoral autoimmune response to nucleophosmin in the immunodiagnosis of hepatocellular carcinoma.Oncology reports · 2015Article
- Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy.Human molecular genetics · 2014Article
- Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.The Journal of biological chemistry · 2012Article
- RNA content in the nucleolus alters p53 acetylation via MYBBP1A.The EMBO journal · 2011Article
- Increased expression of nucleophosmin/B23 in hepatocellular carcinoma and correlation with clinicopathological parameters.British journal of cancer · 2007Article
- The nucleolus: a model for the organization of nuclear functions.Histochemistry and cell biology · 2006Review
- Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-binding proteins.Nucleic acids research · 2002Article
- Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription.The Journal of cell biology · 2002Article
- A novel karyoskeletal protein: characterization of protein NO145, the major component of nucleolar cortical skeleton in Xenopus oocytes.Molecular biology of the cell · 2001Article
- Functional architecture in the cell nucleus.The Biochemical journal · 2001Review
- Nucleolar assembly of the rRNA processing machinery in living cells.The Journal of cell biology · 2001Article
- Assembly and disassembly of the nucleolus during the cell cycle.Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription and splicing of messenger RNAs are temporally and spatially coordinated through the recruitment by RNA polymerase II of processing factors. We questioned whether RNA polymerase I plays a role in the recruitment of the ribosomal RNA (rRNA) processing machinery. During Xenopus laevis embryogenesis, recruitment of the rRNA processing machinery to the nucleolar domain occurs in two steps: two types of precursor structures called prenucleolar bodies (PNBs) form independently throughout the nucleoplasm; and components of PNBs I (fibrillarin, nucleolin, and the U3 and U8 small nucleolar RNAs) fuse to the nucleolar domain before components of PNBs II (B23/NO38). This fusion process is independent of RNA polymerase I activity, as shown by actinomycin D treatment of embryos and by the lack of detectable RNA polymerase I at ribosomal gene loci during fusion. Instead, this process is concomitant with the targeting of maternally derived pre-rRNAs to the nucleolar domain. Absence of fusion was correlated with absence of these pre-rRNAs in nuclei where RNA polymerase II and III are inhibited. Therefore, during X. laevis embryogenesis, the recruitment of the rRNA processing machinery to the nucleolar domain could be dependent on the presence of pre-rRNAs, but is independent of either zygotic RNA polymerase I transcription or the presence of RNA polymerase I itself.
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