ArticleInfection and immunity2000
Invasion of the brain and chronic central nervous system infection after systemic Mycobacterium avium complex infection in mice.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion.Cell reports · 2025Article
- Review
- Etiological and Radiological Spectrum of Longitudinal Myelitis: A Hospital-Based Study in North East India.Journal of neurosciences in rural practice · 2021Article
- CNS infection and immune privilege.Nature reviews. Neuroscience · 2018Review
- Review
- Adjunctive role of MMP-9 inhibition along with conventional anti-tubercular drugs against experimental tuberculous meningitis.International journal of experimental pathology · 2016Article
- Role of Mycobacterium tuberculosis pknD in the pathogenesis of central nervous system tuberculosis.BMC microbiology · 2012Article
- Modelling of Cerebral Tuberculosis: Hope for Continuous Research in Solving the Enigma of the Bottom Billion's Disease.The Malaysian journal of medical sciences : MJMS · 2011Article
- Pathogenesis of central nervous system tuberculosis.Current molecular medicine · 2009Review
- Identification of Mycobacterium avium pathogenicity island important for macrophage and amoeba infection.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Mycobacterium avium invades the intestinal mucosa primarily by interacting with enterocytes.Infection and immunity · 2001Article
- Mycobacterium avium-intracellulare contamination of mammalian cell cultures.In vitro cellular & developmental biology. AnimalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central nervous system (CNS) infections caused by nontuberculous mycobacteria have been described previously, especially in patients with AIDS. To investigate specific aspects of the pathogenesis of this entity, C57BL bg(+)/bg(-) mice were infected intravenously with Mycobacterium avium, and cultures of blood and brain as well as histopathology examination of brain tissue were carried out at several time points up to 6 months after infection. Low-grade inflammatory changes with small aggregates of lymphocytes and macrophages as well as perivascular cuffing were seen early in the infection. A small number of bacteria could be observed in the parenchyma of the choroid plexus. Six months after infection, numerous bacteria were present within the foamy macrophage of the granulomatous lesions along the ventricle and meninges. None of the mice developed clinical signs of meningitis or encephalitis or even died spontaneously during the period of observation. Use of CD18(-/-) knockout mice indicated that transport of the bacterium within neutrophils or monocytes into the brain is unlikely. Mild chronic CNS infection developed in the mice during sustained systemic M. avium infection, similar to what has been reported in most human cases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.