ArticleInfection and immunity2000
Human immune responses to Schistosoma mansoni vaccine candidate antigens.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Immune response induced in vitro by CD16- and CD16+ monocyte-derived dendritic cells in patients with metastatic renal cell carcinoma treated with dendritic cell vaccines.Journal of clinical immunology · 2004Trial
- Effects of Immunization with RecombinantPathogens (Basel, Switzerland) · 2023Article
- Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae.PLoS neglected tropical diseases · 2021Article
- Bacillus subtilis spore with surface display of paramyosin from Clonorchis sinensis potentializes a promising oral vaccine candidate.Parasites & vectors · 2018Article
- Early Induction of Human Regulatory Dermal Antigen Presenting Cells by Skin-PenetratingFrontiers in immunology · 2018Article
- Structure-function analysis of apical membrane-associated molecules of the tegument of schistosome parasites of humans: prospects for identification of novel targets for parasite control.British journal of pharmacology · 2015Review
- Still hope for schistosomiasis vaccine.Human vaccines & immunotherapeutics · 2015Article
- Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment.PLoS neglected tropical diseases · 2015Article
- Parasitic antigens alter macrophage polarization during Schistosoma japonicum infection in mice.Parasites & vectors · 2014Article
- Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases.Frontiers in genetics · 2014Review
- Novel therapeutic and prevention approaches for schistosomiasis: review.Journal of advanced research · 2013Review
- Glycoconjugates in host-helminth interactions.Frontiers in immunology · 2013Review
- Helminth infections and host immune regulation.Clinical microbiology reviews · 2012Review
- Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil.The American journal of tropical medicine and hygiene · 2012Article
- Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosoma mansoni Infection.Journal of parasitology research · 2012Article
- Article
- Acquired immune heterogeneity and its sources in human helminth infection.Parasitology · 2011Review
- Vaccines to combat the neglected tropical diseases.Immunological reviews · 2011Review
- Article
- Molecular cloning and characterization of a paramyosin from Clonorchis sinensis.The Korean journal of parasitology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
To determine the naturally occurring immunological responses to the Schistosoma mansoni antigens paramyosin, IrV-5, Sm-23 (MAP-3), and triose phosphate isomerase (MAP-4), a total of 119 subjects from an area of endemicity for schistosomiasis, including "resistant" subjects (n = 17) were evaluated. Specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, and IgA levels for each of the antigens and the cytokine profile in culture supernatants from antigen-stimulated peripheral blood mononuclear cells (PBMC) were determined. Although all the subjects had a high degree of contaminated water exposure, their infection levels were variable (0 to 1,128 eggs/g of stool). There were direct correlations between infection levels and levels of SWAP- and paramyosin-specific IgG1 and IgG4 (P < 0.05). However, an inverse correlation between infection levels and specific IgG2 to IrV-5 (P < 0.01) was observed. The evaluation of the cytokine profile (interleukin 5 [IL-5], IL-10, gamma interferon [IFN-gamma], and tumor necrosis factor alpha) in response to these antigens showed inverse correlations between the degree of infection and IFN-gamma levels in PBMC supernatants stimulated with paramyosin (P < 0.05) and IrV-5 (P < 0.01). Additionally, inverse correlations between the degree of infection and IL-5 levels in MAP-3- and MAP-4-stimulated PBMC supernatants (P < 0.01) were found. Logistic regression analysis was performed to adjust the results of cytokine profile by age. IL-5 production in MAP-3-stimulated PBMC supernatants was associated with lower infection levels (odds ratio = 11.2 [95% confidence interval, 2.7 to 45.8]).
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