ArticleInfection and immunity2000
Pathogenic mycobacteria disrupt the macrophage actin filament network.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 73 citations in OpenAlex.
- A Phosphoproteomic Analysis of Mycobacterial PknG-Mediated Host Immune Evasion.Journal of proteome research · 2025Article
- Exploring host-pathogen interactions in the Dictyostelium discoideum-Mycobacterium marinum infection model of tuberculosis.Disease models & mechanisms · 2024Review
- Proteomic analysis of granulomas from cattle and pigs naturally infected withFrontiers in immunology · 2024Article
- MIDESP: Mutual Information-Based Detection of Epistatic SNP Pairs for Qualitative and Quantitative Phenotypes.Biology · 2021Article
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- Regulation, Activation and Function of Caspase-11 during Health and Disease.International journal of molecular sciences · 2021Review
- General Overview of Nontuberculous Mycobacteria Opportunistic Pathogens:Journal of clinical medicine · 2020Review
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- March ofClinical & translational immunology · 2020Review
- Dynamic Remodeling of the Host Cell Membrane by Virulent Mycobacterial Sulfoglycolipid-1.Scientific reports · 2019Article
- Mycobacterium tuberculosis infection of host cells in space and time.FEMS microbiology reviews · 2019Review
- Wnt Signaling: Pathogen Incursion and Immune Defense.Frontiers in immunology · 2019Review
- CD82 hypomethylation is essential for tuberculosis pathogenesis via regulation of RUNX1-Rab5/22.Experimental & molecular medicine · 2018Article
- ArfGAP1 restrictsEMBO reports · 2018Article
- Mycobacterial Dormancy Systems and Host Responses in Tuberculosis.Frontiers in immunology · 2017Review
- A review on host-pathogen interactions: classification and prediction.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Review
- The Caenorhabditis elegans p38 MAPK Gene plays a key role in protection from mycobacteria.MicrobiologyOpen · 2016Article
- The mechanism of cytoskeleton protein β-actin and cofilin-1 of macrophages infected by Mycobacterium avium.American journal of translational research · 2016Article
- Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance.Scientific reports · 2015Article
- Differential transcriptional response in macrophages infected with cell wall deficient versus normal Mycobacterium Tuberculosis.International journal of biological sciences · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Phagosomes with pathogenic mycobacteria retain fusion and intermingling characteristics of early endosomes indefinitely. The time course of acquisition of newly endocytosed tracers becomes, however, atypical (lag instead of immediate acquisition) starting from day 1 postinfection (p.i.), thereby suggesting that additional factors affect this process. Disruption of the actin filament (F-actin) network by cytochalasin D perturbs the movement of early endosomes and probably fusion events among early endosomes and phagosomes. Here we compare, by immunofluorescence microscopy, the morphology and distribution of F-actin in macrophages infected with virulent Mycobacterium avium, in uninfected macrophages, or in macrophages after phagocytosis of nonpathogenic bacteria (Mycobacterium smegmatis or Bacillus subtilis) or hydrophobic latex particles. In uninfected cells, F-actin appeared as a network of small filaments distributed throughout the cell; about 80% of the cells also displayed one or two small patches of F-actin at the cell periphery. Virulent M. avium caused a marked disorganization of the F-actin network starting from day 1 p.i. The most salient features were the formation of several large patches, the progressive disappearance of the small filaments, and the appearance of large numbers of tiny punctate structures starting from day 2 p.i. With the three other particles, the F-actin network was unmodified compared to that in uninfected cells. The atypical lag in acquisition of newly endocytosed tracers by M. avium-containing phagosomes, therefore, seems to coincide with the disorganization of the F-actin network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.