ArticleInfection and immunity2000
Antigen specificity in experimental bovine tuberculosis.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Identification of Leptospiral Protein Antigens Recognized by WC1Infection and immunity · 2022Article
- Use of antigen-specific interleukin-2 to differentiate between cattle vaccinated with Mycobacterium bovis BCG and cattle infected with M. bovis.Clinical and vaccine immunology : CVI · 2014Article
- Purified protein derivatives of tuberculin--past, present, and future.FEMS immunology and medical microbiology · 2012Review
- T-Cell and Antibody Responses to Mycobacterial Antigens in Tuberculin Skin-Test-Positive Bos indicus and Bos taurus Cattle in Ethiopia.Veterinary medicine international · 2012Article
- Three protein cocktails mediate delayed-type hypersensitivity responses indistinguishable from that elicited by purified protein derivative in the guinea pig model of Mycobacterium tuberculosis infection.Infection and immunity · 2011Article
- Identification of novel Mycobacterium bovis antigens by dissection of crude protein fractions.Clinical and vaccine immunology : CVI · 2009Article
- Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis.Infection and immunity · 2009Article
- Neutrophil-mediated innate immune resistance to mycobacteria.The Journal of clinical investigation · 2007Article
- Analysis of possible factors affecting the specificity of the gamma interferon test in tuberculosis-free cattle herds.Clinical and diagnostic laboratory immunology · 2004Article
- Cellular immune responses induced in cattle by heterologous prime-boost vaccination using recombinant viruses and bacille Calmette-Guérin.Immunology · 2004Article
- Gamma interferon-based immunodiagnosis of tuberculosis: comparison between whole-blood and enzyme-linked immunospot methods.Journal of clinical microbiology · 2004Article
- 1,25-dihydroxyvitamin D3 and development of tuberculosis in cattle.Clinical and diagnostic laboratory immunology · 2003Article
- Expression of L-Selectin (CD62L), CD44, and CD25 on activated bovine T cells.Infection and immunity · 2003Article
- Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics.Infection and immunity · 2002Article
- Vaccination of guinea pigs with DNA encoding the mycobacterial antigen MPB83 influences pulmonary pathology but not hematogenous spread following aerogenic infection with Mycobacterium bovis.Infection and immunity · 2002Article
- Human T cell responses to peptides of the Mycobacterium leprae 45-kD serine-rich antigen.Clinical and experimental immunology · 2002Article
- Intranasal BCG vaccination protects BALB/c mice against virulent Mycobacterium bovis and accelerates production of IFN-gamma in their lungs.Clinical and experimental immunology · 2001Article
- Modulation of Mycobacterium bovis-specific responses of bovine peripheral blood mononuclear cells by 1,25-dihydroxyvitamin D(3).Clinical and diagnostic laboratory immunology · 2001Article
- Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattle.Clinical and diagnostic laboratory immunology · 2001Article
- Distinct response kinetics of gamma interferon and interleukin-4 in bovine tuberculosis.Infection and immunity · 2000Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This report describes the kinetics of T-cell responses to a panel of mycobacterial antigens (PPD-M, PPD-A, ESAT-6, Ag85, 38kD, MPB64, MPB70, MPB83, hsp16.1, hsp65, and hsp70) following experimental infection of cattle with Mycobacterium bovis. Increased antigen-specific lymphocyte proliferation, gamma interferon, and interleukin-2 responses were observed in all calves following infection. Positive lymphocyte proliferation and cytokine responses to PPD-M and ESAT-6 were observed throughout the infection period studied. In contrast, responses to all other antigens were more variable and were not constantly present, suggesting that antigen cocktails rather than individual antigens should be used for immunodiagnosis. The detection of cytokine responses in the absence of lymphocyte proliferation, particularly during the early stages of infection, suggests a role for antigen-specific cytokine readout systems in the early identification of M. bovis infection in cattle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.