ArticleJournal of clinical pathology2000
A study of interval breast cancer within the NHS breast screening programme.
Article in Journal of clinical pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Healthcare and Cancer Treatment Costs of Breast Screening Outcomes among Higher than Average Risk Women.Current oncology (Toronto, Ont.) · 2023Article
- Considerations for Evaluating the Introduction of New Cancer Screening Technology: Use of Interval Cancers to Assess Potential Benefits and Harms.International journal of environmental research and public health · 2022Review
- Breast cancer risk factors by mode of detection among screened women in the Cancer Prevention Study-II.Breast cancer research and treatment · 2021Article
- Annual vs Biennial Screening: Diagnostic Accuracy Among Concurrent Cohorts Within the Ontario Breast Screening Program.Journal of the National Cancer Institute · 2020Article
- Growing concern following compression mammography.BMJ case reports · 2016Article
- Is clinical breast examination important for breast cancer detection?Current oncology (Toronto, Ont.) · 2016Article
- Familial pancreatic cancer: the case for prophylactic pancreatectomy in lieu of serial screening and shared decision making.Case reports in oncological medicine · 2014Article
- Correlation of immunoglobulin G expression and histological subtype and stage in breast cancer.PloS one · 2013Article
- Prognosis in women with interval breast cancer: population based observational cohort study.BMJ (Clinical research ed.) · 2012Article
- Locally advanced breast cancers are more likely to present as Interval Cancers: results from the I-SPY 1 TRIAL (CALGB 150007/150012, ACRIN 6657, InterSPORE Trial).Breast cancer research and treatment · 2012Article
- The Susan G. Komen for the Cure Tissue Bank at the IU Simon Cancer Center: a unique resource for defining the "molecular histology" of the breast.Cancer prevention research (Philadelphia, Pa.) · 2012Article
- Differential expression of prognostic biomarkers between interval and screen-detected breast cancers: does age or family history matter?Breast cancer research and treatment · 2011Article
- Prognostic value of proliferation in invasive breast cancer: a review.Journal of clinical pathology · 2004Review
- Measures of benefit for breast screening from the pathology database for Scotland, 1991-2001.Journal of clinical pathology · 2003Article
- Article
- Discovery of breast cancers within 1 year of a normal screening mammogram: how are they found?Annals of family medicineArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo define the biological nature and malignant potential of interval cancers presenting to a breast unit within the NHS breast screening programme.
methods112 interval cancers were compared with matched, screen detected and symptomatic cancers in terms of their radiographic, histopathological, and immunohistochemical features.
resultsInterval cancers, strictly defined, showed no characteristic radiographic pattern. In terms of size, vascular invasion, lymph node status, and prognosis they were intermediate between screen detected and symptomatic cancers. Within the interval cancers there was an excess of grade 1 and grade 3 tumours, and lesions with a high Ki67 index but immunohistochemistry otherwise failed to discriminate between the three groups. Inclusion of data from false negative "interval cancers" did not significantly alter the results.
conclusionsInterval cancers are more aggressive than screen detected cancers but in general less aggressive than symptomatic cancers. However, within a heterogeneous group, occasional interval cancers are exceptionally malignant.
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