ArticleThe Journal of physiology2000
Plasticity in adult cat visual cortex (area 17) following circumscribed monocular lesions of all retinal layers.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 81 citations in OpenAlex.
- Cortical representation of space around the blind spot.Journal of neurophysiology · 2005Trial
- Macaque Area V2/V3 Reorganization Following Homonymous Retinal Lesions.Frontiers in neuroscience · 2022Article
- NGF Eye Administration Recovers the TrkB and Glutamate/GABA Marker Deficit in the Adult Visual Cortex Following Optic Nerve Crush.International journal of molecular sciences · 2021Article
- Mesoscopic cortical network reorganization during recovery of optic nerve injury in GCaMP6s mice.Scientific reports · 2020Article
- Contextual influences in the peripheral retina of patients with macular degeneration.Scientific reports · 2019Article
- Preserved evoked conscious perception of phosphenes with direct stimulation of deafferented primary visual cortex.Epilepsy & behavior case reports · 2019Article
- Axonal plasticity associated with perceptual learning in adult macaque primary visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Robust Visual Responses and Normal Retinotopy in Primate Lateral Geniculate Nucleus following Long-term Lesions of Striate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Homeostatic plasticity in human extrastriate cortex following a simulated peripheral scotoma.Experimental brain research · 2017Article
- Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats.Neural plasticity · 2017Article
- The Current Status of Somatostatin-Interneurons in Inhibitory Control of Brain Function and Plasticity.Neural plasticity · 2016Review
- Adult cortical plasticity studied with chronically implanted electrode arrays.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Large-scale axonal reorganization of inhibitory neurons following retinal lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Quantification of early stages of cortical reorganization of the topographic map of V1 following retinal lesions in monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- The second face of blindness: processing speed deficits in the intact visual field after pre- and post-chiasmatic lesions.PloS one · 2013Article
- Adult visual cortical plasticity.Neuron · 2012Article
- Article
- Illusory contours over pathological retinal scotomas.PloS one · 2011Article
- Task-dependent V1 responses in human retinitis pigmentosa.Investigative ophthalmology & visual science · 2010Article
- Experience-dependent gene expression in adult visual cortex.Cerebral cortex (New York, N.Y. : 1991) · 2010Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. In eight adult cats intense, sharply circumscribed, monocular laser lesions were used to remove all cellular layers of the retina. The extents of the retinal lesions were subsequently confirmed with counts of alpha-ganglion cells in retinal whole mounts; in some cases these revealed radial segmental degeneration of ganglion cells distal to the lesion. 2. Two to 24 weeks later, area 17 (striate cortex; V1) was studied electrophysiologically in a standard anaesthetized, paralysed (artificially respired) preparation. Recording single- or multineurone activity revealed extensive topographical reorganization within the lesion projection zone (LPZ). 3. Thus, with stimulation of the lesioned eye, about 75 % of single neurones in the LPZ had 'ectopic' visual discharge fields which were displaced to normal retina in the immediate vicinity of the lesion. 4. The sizes of the ectopic discharge fields were not significantly different from the sizes of the normal discharge fields. Furthermore, binocular cells recorded from the LPZ, when stimulated via their ectopic receptive fields, exhibited orientation tuning and preferred stimulus velocities which were indistinguishable from those found when the cells were stimulated via the normal eye. 5. However, the responses to stimuli presented via ectopic discharge fields were generally weaker (lower peak discharge rates) than those to presentations via normal discharge fields, and were characterized by a lower-than-normal upper velocity limit. 6. Overall, the properties of the ectopic receptive fields indicate that cortical mechanisms rather than a retinal 'periphery' effect underlie the topographic reorganization of area 17 following monocular retinal lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.