ArticleThe Journal of physiology2000
Tonotopic variations of calcium signalling in turtle auditory hair cells.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Reproductive-state dependent changes in inner ear gene expression in female plainfin midshipman fish.PloS one · 2026Article
- Comparative study of ionic currents and exocytosis in hair cells of the basilar and amphibian papilla in bullfrogs.Frontiers in cellular neuroscience · 2022Article
- Differential Gene Expression Patterns Between Apical and Basal Inner Hair Cells Revealed by RNA-Seq.Frontiers in molecular neuroscience · 2019Article
- Sensory Hair Cells: An Introduction to Structure and Physiology.Integrative and comparative biology · 2018Review
- Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.Comprehensive Physiology · 2017Review
- Applications for single cell trajectory analysis in inner ear development and regeneration.Cell and tissue research · 2015Review
- Reflections on the role of a traveling wave along the basilar membrane in view of clinical and experimental findings.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Review
- The how and why of identifying the hair cell mechano-electrical transduction channel.Pflugers Archiv : European journal of physiology · 2015Review
- Response properties from turtle auditory hair cell afferent fibers suggest spike generation is driven by synchronized release both between and within synapses.Journal of neurophysiology · 2013Article
- Swept field laser confocal microscopy for enhanced spatial and temporal resolution in live-cell imaging.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2012Article
- Biophysical properties of CaV1.3 calcium channels in gerbil inner hair cells.The Journal of physiology · 2008Article
- Calcium-dependent inactivation of calcium channels in cochlear hair cells of the chicken.The Journal of physiology · 2007Article
- Differential trafficking of carboxyl isoforms of Ca2+-gated (Slo1) potassium channels.FEBS letters · 2007Article
- Steady-state adaptation of mechanotransduction modulates the resting potential of auditory hair cells, providing an assay for endolymph [Ca2+].The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels.The Journal of general physiology · 2006Article
- A transiently expressed SK current sustains and modulates action potential activity in immature mouse inner hair cells.The Journal of physiology · 2004Article
- Effects of intracellular stores and extracellular Ca(2+) on Ca(2+)-activated K(+) currents in mature mouse inner hair cells.The Journal of physiology · 2004Article
- Cav1.3 (alpha1D) Ca2+ currents in neonatal outer hair cells of mice.The Journal of physiology · 2003Article
- Presynaptic calcium stores modulate afferent release in vestibular hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Biophysical and pharmacological characterization of voltage-gated calcium currents in turtle auditory hair cells.The Journal of physiology · 2003Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Turtle cochlear hair cells are electrically tuned by a voltage-dependent Ca2+ current and a Ca2+-dependent K+ current (IBK(Ca)). The effects of intracellular calcium buffering on electrical tuning were studied in hair cells at apical and basal cochlear locations tuned to 100 and 300 Hz, respectively. Increasing the intracellular BAPTA concentration changed the hair cell's resonant frequency little, but optimized tuning at more depolarized membrane potentials due to a positive shift in the half-activation voltage (V ) of the IBK(Ca). The shift in V depended similarly on BAPTA concentration in basal and apical hair cells despite a 2. 4-fold difference in the size of the Ca2+ current at the two positions. The Ca2+ current amplitude increased exponentially with distance along the cochlea. Comparison of V values and tuning properties using different BAPTA concentrations with values measured in perforated-patch recordings gave the endogenous calcium buffer as equivalent to 0.21 mM BAPTA in low-frequency cells, and 0.46 mM BAPTA in high-frequency cells. High conductance Ca2+-activated K+ (BKCa) channels recorded in inside-out membrane patches were 2-fold less Ca2+ sensitive in high-frequency than in low-frequency cells. Confocal Ca2+ imaging using the fluorescent indicator Calcium Green-1 revealed about twice as many hotspots of Ca2+ entry during depolarization in high-frequency compared to low-frequency hair cells. We suggest that each BKCa channel is gated by Ca2+ entry through a few nearby Ca2+ channels, and that Ca2+ and BKCa channels occupy, at constant channel density, a greater fraction of the membrane area in high-frequency cells than in low-frequency cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.