ArticleGut2000
Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study.
Article in Gut, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Anthraquinone laxatives use and colorectal cancer: A systematic review and meta-analysis of observational studies.Phytotherapy research : PTR · 2022Pooled it
- Colorectal neoplasms in melanosis coli: a survey in Japan and a worldwide meta-analysis.International journal of colorectal disease · 2021Pooled it
- Lack of objective evidence of efficacy of laxatives in chronic constipation.Digestive diseases and sciences · 2002Pooled it
- Impact of Constipation on Quality of Life, Work Productivity, and Treatment Practices: Findings from the CONNECT Web-Based Survey.Digestion · 2026Article
- Zengye decoction regulated the expression of aquaporin in colon tissue of rats with constipation through miR-10a-5p targeting Drd2/AC/cAMP axis.Histology and histopathology · 2025Article
- Effect of laxative use and laxative type on colorectal cancer risk: A pooling up analysis and evidence synthesis.Oncology letters · 2025Article
- Constipation among workers with depression/anxiety: a retrospective study using a claims database and survey data in Japan.BMJ open · 2024Observational
- Review article: do stimulant laxatives damage the gut? A critical analysis of current knowledge.Therapeutic advances in gastroenterology · 2024Review
- State of the Art Bowel Management for Pediatric Colorectal Problems: Spinal Anomalies.Children (Basel, Switzerland) · 2023Review
- Review on melanosis coli and anthraquinone-containing traditional Chinese herbs that cause melanosis coli.Frontiers in pharmacology · 2023Review
- Intraoperative discovery of melanosis coli during emergent bowel resection for perforation.BMJ case reports · 2022Article
- Severe grade of melanosis coli is associated with a higher detection rate of colorectal adenoma.Journal of clinical biochemistry and nutrition · 2022Article
- Increased Colonic Fluorodeoxyglucose Uptake in Melanosis Coli-A Case Series of Three Patients.Gastro hep advances · 2022Article
- Case report: Melanosis coli combined with colon cancer, causality or coincidence?Frontiers in surgery · 2022Article
- Pseudomelanosis coli, its relation to laxative use and association with colorectal neoplasms: A comprehensive review.JGH open : an open access journal of gastroenterology and hepatology · 2021Review
- Retrospective study on melanosis coli as risk factor of colorectal neoplasm: a 3-year colonoscopic finding in Zhuhai Hospital, China.International journal of colorectal disease · 2020Article
- Association between anthraquinone laxatives and colorectal cancer: protocol for a systematic review and meta-analysis.Systematic reviews · 2020Article
- Daiokanzoto (Da-Huang-Gan-Cao-Tang) is an effective laxative in gut microbiota associated with constipation.Scientific reports · 2019Article
- Laxative type in relation to colorectal cancer risk.Annals of epidemiology · 2018Article
- Gender, age, and concomitant diseases of melanosis coli in China: a multicenter study of 6,090 cases.PeerJ · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnthranoid laxatives are the most commonly used purgatives in the therapy of acute and chronic constipation. Recent experimental data and a prospective cohort study provide evidence of a possible risk of anthranoid use for the development of colorectal neoplasms. MATERIALS AND
methodsWe performed a prospective case control study at the University of Erlangen to investigate the risk of anthranoid laxative use for the development of colorectal adenomas or carcinomas. A total of 202 patients with newly diagnosed colorectal carcinomas, 114 patients with adenomatous polyps, and 238 patients (controls) with no colorectal neoplasms who had been referred for total colonoscopy were studied. The use of anthranoid preparations was assessed by standardised interview, and endoscopically visible or microscopic melanosis coli was studied by histopathological examination.
resultsThere was no statistically significant risk of anthranoid use for the development of colorectal adenomas (unadjusted odds ratio 1.0; 95% CI 0.5-1.9) or carcinomas (unadjusted odds ratio 1.0; 95% CI 0.6-1.8). Even after adjustment for the risk factors age, sex, and blood in the stools by logistic regression analysis the odds ratio for adenomas was 0.84 (95% CI 0. 4-1.7) and for carcinomas 0.93 (95% CI 0.5-1.7). Also, there were no differences between the patient and control groups for duration of intake. Macroscopic and high grade microscopic melanosis coli were not significant risk factors for the development of adenomas or carcinomas.
conclusionNeither anthranoid laxative use, even in the long term, nor macroscopic or marked microscopic melanosis coli were associated with any significant risk for the development of colorectal adenoma or carcinoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.