ArticleGut2000
alpha-catenin expression is decreased in human gastric cancers and in the gastric mucosa of first degree relatives.
Article in Gut, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- The Role of CTNNA1 in Malignancies: An Updated Review.Journal of Cancer · 2023Review
- The Chemical Potential of Plasma Membrane Cholesterol: Implications for Cell Biology.Biophysical journal · 2018Article
- Bifidobacterium bifidum PRL2010 modulates the host innate immune response.Applied and environmental microbiology · 2014Article
- Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells.The Journal of biological chemistry · 2009Article
- Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.Seminars in cancer biology · 2008Review
- Syndrome differentiation in traditional Chinese medicine and E-cadherin/ICAM-1 gene protein expression in gastric carcinoma.World journal of gastroenterology · 2007Article
- Effects of Helicobacter pylori on the cadherin-catenin complex.Journal of clinical pathology · 2006Article
- Elevated risk for gastric adenocarcinoma can be predicted from histomorphology.World journal of gastroenterology · 2006Review
- Eradication of H pylori for the prevention of gastric cancer.World journal of gastroenterology · 2006Review
- Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas.World journal of gastroenterology · 2006Article
- Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients.World journal of gastroenterology · 2005Article
- Alpha-catenin expression is decreased in patients with gastric carcinoma.World journal of gastroenterology · 2005Article
- Beta-catenin gene alteration in glandular stomach adenocarcinomas in N-methyl-N-nitrosourea-treated and Helicobacter pylori-infected Mongolian gerbils.Cancer science · 2004Article
- Effects of c9,t11-conjugated linoleic acid on adhesion of human gastric carcinoma cell line SGC-7901.World journal of gastroenterology · 2004Article
- Expression of E-cadherin and beta-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival.World journal of gastroenterology · 2002Article
- Increased expression of survivin in gastric cancer patients and in first degree relatives.British journal of cancer · 2002Article
- Expression of G1 phase cyclins in human gastric cancer and gastric mucosa of first-degree relatives.Digestive diseases and sciences · 2002Article
- Helicobacter pylori infection and molecular changes in gastric carcinogenesis.Journal of gastroenterology · 2002Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe role of altered cell adhesion is critical for the development of epithelial cancers. E-cadherin plays an important role in the maintenance of cell-cell adhesion and its function is thought to be regulated by its associated cytoplasmic proteins, such as alpha-catenin and beta-catenin. To determine the role of alpha-catenin expression in gastric carcinogenesis, we studied its expression in human gastric cancer and in the gastric mucosa of first degree relatives with no clinical disease.
methodsalpha-Catenin expression was assessed by immunohistochemical analysis and reverse transcriptase-polymerase chain reaction (RT-PCR) using gastric tissue specimens from patients with gastric cancer and from the gastric mucosa of first degree relatives of gastric cancer patients and healthy controls.
resultsmRNA levels of alpha-catenin were reduced or absent in 13 of 19 gastric cancer tissues, which differed significantly from levels found in the tumour free gastric mucosa of cancer patients (p<0.05). Of the cancer samples with altered alpha-catenin mRNA levels, alpha-catenin expression was negative in seven and decreased in six cases. Interestingly, decreased alpha-catenin mRNA expression also occurred in the mucosa of the corpus (11/18) and antrum (4/18) of first degree relatives. In the corpus biopsies alpha-catenin expression was more often decreased or lost compared with the antrum biopsies in first degree relatives and healthy controls (p<0.05). Immunohistochemical analysis revealed membranous expression of alpha-catenin in gastric cancer cells and the non-malignant gastric epithelium. However, some cancers also exhibited loss of membranous staining. Generally, loss or downregulation of alpha-catenin mRNA in the gastric mucosa was associated with Helicobacter pylori infection (p<0.05).
conclusionOur findings suggest that loss or downregulation of alpha-catenin expression may be an early event in gastric carcinogenesis and may be associated with H pylori infection.
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