ArticleBrain pathology (Zurich, Switzerland)2000
Microglial activation and neuronal apoptosis in Bornavirus infected neonatal Lewis rats.
Article in Brain pathology (Zurich, Switzerland), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 95 citations in OpenAlex.
- Ex vivo study of neuroinvasive and neurotropic viruses: what is current and what is next.FEMS microbiology reviews · 2025Review
- Prenatal SARS-CoV-2 infection results in neurodevelopmental and behavioral outcomes in mice.JCI insight · 2024Article
- Avian Bornavirus Research-A Comprehensive Review.Viruses · 2022Review
- Immunopathology of Fatal Human Variegated Squirrel Bornavirus 1 Encephalitis, Germany, 2011-2013.Emerging infectious diseases · 2019Article
- Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production.Journal of virology · 2017Article
- Interferon gamma protects neonatal neural stem/progenitor cells during measles virus infection of the brain.Journal of neuroinflammation · 2016Article
- Distribution and characterization of tumor-associated macrophages/microglia in rat C6 glioma.Oncology letters · 2015Article
- Neonatal infection modulates behavioral flexibility and hippocampal activation on a Morris Water Maze task.Physiology & behavior · 2014Article
- The bicolored white-toothed shrew Crocidura leucodon (HERMANN 1780) is an indigenous host of mammalian Borna disease virus.PloS one · 2014Article
- Borna disease virus infects human neural progenitor cells and impairs neurogenesis.Journal of virology · 2012Article
- Intracerebral Borna disease virus infection of bank voles leading to peripheral spread and reverse transcription of viral RNA.PloS one · 2011Article
- Animal models of CNS viral disease: examples from borna disease virus models.Interdisciplinary perspectives on infectious diseases · 2010Article
- Apoptosis in animal models of virus-induced disease.Nature reviews. Microbiology · 2009Review
- Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection.Journal of neuroinflammation · 2008Article
- Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis.The Journal of experimental medicine · 2008Article
- Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus.Journal of neuroinflammation · 2008Article
- Altered development of the brain after focal herpesvirus infection of the central nervous system.The Journal of experimental medicine · 2008Article
- Hippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection.Journal of virology · 2008Article
- Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection.Future virology · 2008Article
- Downregulation of an astrocyte-derived inflammatory protein, S100B, reduces vascular inflammatory responses in brains persistently infected with Borna disease virus.Journal of virology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Lewis rats neonatally infected with Borna disease virus have a behavioral syndrome characterized by hyperactivity, movement disorders, and abnormal social interactions. Virus is widely distributed in brain; however, neuropathology is focused in dentate gyrus, cerebellum, and neocortex where granule cells, Purkinje cells and pyramidal cells are lost through apoptosis. Although a transient immune response is present, its distribution does not correlate with sites of damage. Neuropathology is instead colocalized with microglial proliferation and expression of MHC class I and class II, ICAM, CD4 and CD8 molecules. Targeted pathogenesis in this system appears to be linked to microglial activation and susceptibility of specific neuronal populations to apoptosis rather than viral tropism or virus-specific immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.