ArticleAmerican journal of human genetics2000
Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Epigenetic and Transcriptional Shifts in Human Neural Stem Cells after Reprogramming into Induced Pluripotent Stem Cells and Subsequent Redifferentiation.International journal of molecular sciences · 2024Article
- Massive Loss of Transcription Factors Promotes the Initial Diversification of Placental Mammals.International journal of molecular sciences · 2022Article
- Role of the zinc finger and SCAN domain-containing transcription factors in cancer.American journal of cancer research · 2019Review
- Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement.Nature reviews. Endocrinology · 2018Review
- 11p15.4 Microdeletion Associates with Hemihypertrophy.Case reports in genetics · 2018Article
- Inter- and intra-patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from circulating and lymph nodal compartments.British journal of haematology · 2016Article
- The evolution of reproduction-related NLRP genes.Journal of molecular evolution · 2014Article
- Reduced transcript expression of genes affected by inherited and de novo CNVs in autism.European journal of human genetics : EJHG · 2011Article
- DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle.BMC genetics · 2010Article
- CAMOS, a nonprogressive, autosomal recessive, congenital cerebellar ataxia, is caused by a mutant zinc-finger protein, ZNF592.European journal of human genetics : EJHG · 2010Article
- Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression.PLoS genetics · 2008Article
- Article
- Functional analysis of p53 binding under differential stresses.Molecular and cellular biology · 2006Article
- Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif.Molecular and cellular biology · 2004Article
- High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The SCAN domain of ZNF174 is a dimer.The Journal of biological chemistry · 2002Article
- Genomic analysis of orthologous mouse and human olfactory receptor loci.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- All in the family: the BTB/POZ, KRAB, and SCAN domains.Molecular and cellular biology · 2001Review
- A phylogenetic approach to gene expression data: evidence for the evolutionary origin of mammalian leukocyte phenotypes.Evolution & developmentArticle
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
The genetics of Beckwith-Wiedemann syndrome (BWS) is complex and is thought to involve multiple genes. It is known that three regions on chromosome 11p15 (BWSCR1, BWSCR2, and BWSCR3) may play a role in the development of BWS. BWSCR2 is defined by two BWS breakpoints. Here we describe the cloning and sequence analysis of 73 kb containing BWSCR2. Within this region, we detected a novel zinc-finger gene, ZNF215. We show that two of its five alternatively spliced transcripts are disrupted by both BWSCR2 breakpoints. Parts of the 3' end of these splice forms are transcribed from the antisense strand of a second zinc-finger gene, ZNF214. We show that ZNF215 is imprinted in a tissue-specific manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.