ArticleInternational journal of experimental pathology2000
Antiviral effect of nitric oxide during Japanese encephalitis virus infection.
Article in International journal of experimental pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Host-virus interaction and viral evasion.Cell biology international · 2021Review
- Fc receptors in antibody-dependent enhancement of viral infections.Immunological reviews · 2015Review
- West Nile Virus Challenge Alters the Transcription Profiles of Innate Immune Genes in Rabbit Peripheral Blood Mononuclear Cells.Frontiers in veterinary science · 2015Article
- Review
- Cell-intrinsic innate immune control of West Nile virus infection.Trends in immunology · 2012Review
- Nitric oxide in dengue and dengue haemorrhagic fever: necessity or nuisance?FEMS immunology and medical microbiology · 2009Review
- Recombinant core proteins of Japanese encephalitis virus as activators of the innate immune response.Virus genes · 2009Article
- Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection.Journal of virology · 2006Article
- Arginine metabolism during macrophage autocrine activation and infection with mouse hepatitis virus 3.Immunobiology · 2004Article
- Pathogenesis of flavivirus encephalitis.Advances in virus research · 2003Review
- Alteration in plasma glucose levels in Japanese encephalitis patients.International journal of experimental pathology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of Japanese encephalitis virus (JEV) and JEV-induced macrophage derived neutrophil chemotactic factor (MDF) to produce nitric oxide (NO), and the possible antiviral effect of NO during JEV infection, was investigated. Splenic macrophages of JEV infected mice produced maximum NO in vivo at day 7 post infection, and in vitro at 24 h after JEV stimulation. MDF-induced NO production was dose dependent and maximal at 60 min after MDF treatment. The response was sensitive to anti-MDF antibody treatment and the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (L-NMMA). Pretreatment of mice with L-NMMA increased the mortality to 100% in JEV infected mice in vivo and inhibited NO production in vitro, while MDF stimulated macrophages inhibited virus replication with high levels of NO production. MDF treatment increased the survival rate of JEV infected mice. The findings thus demonstrate that MDF induces production of NO during JEV infection, which has an antiviral effect. This may be one of the important mechanisms of natural immunity in controlling the initial stages of JEV infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.