ArticleInternational journal of experimental pathology2000
Epithelial stem cell repertoire in the gut: clues to the origin of cell lineages, proliferative units and cancer.
Article in International journal of experimental pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Cellular stress and epigenetic regulation in adult stem cells.Life science alliance · 2024Review
- Gut-on-a-chip models for dissecting the gut microbiology and physiology.APL bioengineering · 2023Review
- Human Intestinal Organoids: Promise and Challenge.Frontiers in cell and developmental biology · 2022Review
- Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon.Cancer prevention research (Philadelphia, Pa.) · 2022Article
- Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo.Journal of extracellular vesicles · 2021Article
- 3D cyclorama for digital unrolling and visualisation of deformed tubes.Scientific reports · 2021Article
- Age-related changes in intestinal immunity and the microbiome.Journal of leukocyte biology · 2021Review
- Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels.The Journal of pathology · 2019Article
- Active β-Catenin Signaling in the Small Intestine of Humans During Infancy.Digestive diseases and sciences · 2019Article
- Tumor heterogeneity of gastric cancer: From the perspective of tumor-initiating cell.World journal of gastroenterology · 2018Review
- β-catenin, leucine-rich repeat-containing G protein-coupled receptor 5 and GATA-binding factor 6 are associated with the normal mucosa-adenoma-adenocarcinoma sequence of colorectal tumorigenesis.Oncology letters · 2018Article
- Optimizing homeostatic cell renewal in hierarchical tissues.PLoS computational biology · 2018Article
- Translationally-controlled tumor protein activates the transcription of Oct-4 in kidney-derived stem cells.Experimental and therapeutic medicine · 2017Article
- Identification and isolation of kidney-derived stem cells from transgenic rats with diphtheria toxin-induced kidney damage.Experimental and therapeutic medicine · 2016Article
- DNA Methylation Dynamics During Differentiation, Proliferation, and Tumorigenesis in the Intestinal Tract.Stem cells and development · 2015Review
- Tissue underlying the intestinal epithelium elicits proliferation of intestinal stem cells following cytotoxic damage.Cell and tissue research · 2015Article
- Stem cell dynamics in homeostasis and cancer of the intestine.Nature reviews. Cancer · 2014Review
- Intestinal stem cells remain viable after prolonged tissue storage.Cell and tissue research · 2013Article
- Progastrin stimulates colonic cell proliferation via CCK2R- and β-arrestin-dependent suppression of BMP2.Gastroenterology · 2013Article
- Regulatory T cells and immune tolerance in the intestine.Cold Spring Harbor perspectives in biology · 2013Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastrointestinal stem cells are shown to be pluripotential and to give rise to all cell lineages in the epithelium. After damage, gut stem cells produce reparative cell lineages that produce a wide range of peptides with important actions on cell proliferation and migration, and promote regeneration and healing. Increase in stem cell number is considered to induce crypt fission, and lead to increases in the number of crypts, even in the adult; it is also the mode of spread of mutated clones in the colorectal mucosa. Stem cell repertoire is defined by both intrinsic programming of the stem cell itself, but signalling from the mesenchyme is also vitally important for defining both stem cell progeny and proliferation. Carcinogenesis in the colon occurs through sequential mutations, possibly occurring in a single cell. A case is made for this being the stem cell, but recent studies indicate that several stem cells may need to be so involved, since early lesions appear to be polyclonal in derivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.