ReviewInternational journal of experimental pathology2000
The clonal origin and clonal evolution of epithelial tumours.
Review in International journal of experimental pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- The first experimental demonstration of the clonal origin of cancer.Haematologica · 2025Article
- Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development.Disease models & mechanisms · 2022Article
- Review
- The cellular origins of cancer with particular reference to the gastrointestinal tract.International journal of experimental pathology · 2020Review
- Intratumoral Heterogeneity in Ductal Carcinoma In Situ: Chaos and Consequence.Journal of mammary gland biology and neoplasia · 2018Review
- Biomarkers: paving stones on the road towards the personalized precision medicine for oral squamous cell carcinoma.BMC cancer · 2018Review
- Microsatellites within the feline androgen receptor are suitable for X chromosome-linked clonality testing in archival material.Journal of feline medicine and surgery · 2017Article
- Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy.Cancer metastasis reviews · 2014Review
- Protective effect of caffeine on ethyl methanesulfonate-induced wing primordial cells of Drosophila melanogaster.Toxicology international · 2014Article
- Advances for studying clonal evolution in cancer.Cancer letters · 2013Review
- Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer.Cancer letters · 2012Article
- The growth pattern of transplanted normal and nodular hepatocytes.Histochemistry and cell biology · 2011Article
- Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer.PloS one · 2011Article
- Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma.World journal of gastroenterology · 2009Article
- Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas.Cancer prevention research (Philadelphia, Pa.) · 2008Article
- Liver repopulation and carcinogenesis: two sides of the same coin?The American journal of pathology · 2008Review
- Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer.Gene therapy · 2008Review
- Clonal diversity in carcinomas: its implications for tumour progression and the contribution made to it by epithelial-mesenchymal transitions.Clinical & experimental metastasis · 2008Review
- Intratumoral patterns of clonal evolution in meningiomas as defined by multicolor interphase fluorescence in situ hybridization (FISH): is there a relationship between histopathologically benign and atypical/anaplastic lesions?The Journal of molecular diagnostics : JMD · 2004Article
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the origin of tumours, whether from one cell or many, has been a source of fascination for experimental oncologists for some time, in recent years there has been a veritable explosion of information about the clonal architecture of tumours and their antecedents, stimulated, in the main, by the ready accessibility of new molecular techniques. While most of these new results have apparently confirmed the monoclonal origin of human epithelial (and other) tumours, there are a significant number of studies in which this conclusion just cannot be made. Moreover, analysis of many articles show that the potential impact of such considerations as patch size and clonal evolution on determinations of clonality have largely been ignored, with the result that a number of these studies are confounded. However, the clonal architecture of preneoplastic lesions provide some interesting insights --many lesions which might have been hitherto regarded as hyperplasias are apparently clonal in derivation. If this is indeed true, it calls into some question our hopeful corollary that a monoclonal origin presages a neoplastic habitus. Finally, it is clear, for many reasons, that methods of analysis which involve the disaggregation of tissues, albeit microdissected, are far from ideal and we should be putting more effort into techniques where the clonal architecture of normal tissues, preneoplastic and preinvasive lesions and their derivative tumours can be directly visualized in situ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.