ArticleThe European journal of neuroscience2000
Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of mu and delta receptor activation on proliferation and neurite elongation.
Article in The European journal of neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 104 citations in OpenAlex.
- Impact of Intrauterine Insults on Fetal and Postnatal Cerebellar Development in Humans and Rodents.Cells · 2024Review
- Evaluation of histological and ultrastructural changes provoked by prenatal tramadol on postnatal cortical cerebellar neuronal development in rats: possible implication of Ki67, GFAP and MicroRNA-7/P53 signalling trajectories.Journal of molecular histology · 2024Article
- Buprenorphine and methadone differentially alter early brain development in human cortical organoids.Neuropharmacology · 2023Article
- Role of Brain Modulators in Neurodevelopment: Focus on Autism Spectrum Disorder and Associated Comorbidities.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Endogenous Opioids and Their Role in Stem Cell Biology and Tissue Rescue.International journal of molecular sciences · 2022Review
- Origin, Development, and Synaptogenesis of Cortical Interneurons.Frontiers in neuroscience · 2022Review
- A potential role for somatostatin signaling in regulating retinal neurogenesis.Scientific reports · 2021Article
- Commentary - Cerebellar underdevelopment in the very preterm infant: Important and underestimated source of cognitive deficits.Journal of neonatal-perinatal medicine · 2021Article
- Dentate gyrus μ-opioid receptor-mediated neurogenic processes are associated with alterations in morphine self-administration.Scientific reports · 2019Article
- Fentanyl Induces Cerebellar Internal Granular Cell Layer Apoptosis in Healthy Newborn Pigs.Frontiers in neurology · 2018Article
- Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System.Frontiers in pediatrics · 2017Review
- Brain Injury and Development in Preterm Infants Exposed to Fentanyl.The Annals of pharmacotherapy · 2015Article
- Recent advances on the δ opioid receptor: from trafficking to function.British journal of pharmacology · 2015Review
- μ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche.Addiction biology · 2014Article
- Prenatal morphine exposure reduces pyramidal neurons in CA1, CA2 and CA3 subfields of mice hippocampus.Iranian journal of basic medical sciences · 2014Article
- Article
- Crosstalk between delta opioid receptor and nerve growth factor signaling modulates neuroprotection and differentiation in rodent cell models.International journal of molecular sciences · 2013Article
- Introduction to the special issue "Pharmacotherapies for the treatment of alcohol abuse and dependence" and a summary of patents targeting other neurotransmitter systems.Recent patents on CNS drug discovery · 2012Article
- Purkinje cells loss in off spring due to maternal morphine sulfate exposure: a morphometric study.Anatomy & cell biology · 2012Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Although opioids are known to affect neurogenesis in vivo, it is uncertain the extent to which opioids directly or indirectly affect the proliferation, differentiation or death of neuronal precursors. To address these questions, the intrinsic role of the opioid system in neurogenesis was systematically explored in cerebellar external granular layer (EGL) neuronal precursors isolated from postnatal mice and maintained in vitro. Isolated neuronal precursors expressed proenkephalin-derived peptides, as well as specific mu and delta, but negligible kappa, opioid receptors. The developmental effects of opioids were highly selective. Morphine-induced mu receptor activation inhibited DNA synthesis, while a preferential delta2-receptor agonist ([D-Ala2]-deltorphin II) or Met-enkephalin, but not the delta1 agonist [D-Pen2, D-Pen5]-enkephalin, inhibited differentiation within the same neuronal population. If similar patterns occur in the developing cerebellum, spatiotemporal differences in endogenous mu and delta opioid ligand-receptor interactions may coordinate distinct aspects of granule neuron maturation. The data additionally suggest that perinatal exposure to opiate drugs of abuse directly interfere with cerebellar maturation by disrupting normal opioid signalling and inhibiting the proliferation of granule neuron precursors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.