ArticleJapanese journal of cancer research : Gann2000
Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract.
Article in Japanese journal of cancer research : Gann, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Glutathione S-transferase M1 null genotype meta-analysis on gastric cancer risk.Diagnostic pathology · 2014Pooled it
- Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and susceptibility to gastric cancer: a meta-analysis.Cancer science · 2006Pooled it
- The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Salivary Proteome Changes in Response to Acute Psychological Stress Due to an Oral Exam Simulation in University Students: Effect of an Olfactory Stimulus.International journal of molecular sciences · 2021Article
- Molecular Bases of Mechanisms Accounting for Drug Resistance in Gastric Adenocarcinoma.Cancers · 2020Review
- Deletion and Single Nucleotide Polymorphisms in Common Glutathione-S Transferases Contribute to Colorectal Cancer Development.Pathology oncology research : POR · 2019Article
- PharmGKB summary: very important pharmacogene information for GSTT1.Pharmacogenetics and genomics · 2012Article
- Expression of the xenobiotic- and reactive oxygen species-detoxifying enzymes, GST-pi, Cu/Zn-SOD, and Mn-SOD in the endocrine cells of colorectal cancer.International journal of colorectal disease · 2010Article
- Decreased expression of GST pi is correlated with a poor prognosis in human esophageal squamous carcinoma.BMC cancer · 2010Article
- The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer.BMC genetics · 2010Article
- Immunohistochemical localization of glutathione S-transferase-pi in human colorectal polyps.World journal of gastroenterology · 2008Article
- Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer.Cancer · 2007Article
- Polymorphisms of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett's esophagus.Journal of human genetics · 2007Article
- GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.World journal of gastroenterology · 2004Article
- Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria.Histochemistry and cell biology · 2004Article
- Glutathione S-transferase-pi expression is downregulated in patients with Barrett's esophagus and esophageal adenocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- A comparison of glutathione S-transferase mutant frequencies in healthy Han and Uygur Chinese.European journal of drug metabolism and pharmacokineticsArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione S-transferases (GSTs) form a family of enzymes, which play an important role in the prevention of cancer by detoxifying numerous potentially carcinogenic compounds. GSTs catalyze the conjugation of glutathione to such harmful molecules, and enable their secretion. Human GSTs can be divided into five main classes. The theta class of isoenzymes was only recently identified and limited (immunohistochemical) data on these enzymes are available. In the present study, paraffin-embedded sections of different gastrointestinal tissues were analyzed immunohistochemically for GSTalpha, GSTP1-1 and GSTT1-1 expression using specific antibodies. GSTalpha, GSTP1-1 and GSTT1-1 were highly expressed in all gastrointestinal tissues examined, with a unique cellular distribution. GSTT1-1 is the first GST isoenzyme demonstrated in duodenal Paneth cells and glands of Brunner. The common expression of GSTalpha, GSTT1-1 and GSTP1-1 in many cell types along the human gastrointestinal tract suggests an important role in the protection against carcinogens and other xenobiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.