ArticleProceedings of the National Academy of Sciences of the United States of America2000
A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Clinical immunology in chromatinopathies: a scoping review.Frontiers in immunology · 2026Article
- Polyfunctional CD8Molecular oncology · 2025Article
- Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD.Frontiers in molecular biosciences · 2022Review
- A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression.Drug development research · 2021Article
- Identification of a Distal Locus Enhancer Element That Controls Cell Type-SpecificJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data.Genome biology · 2020Article
- Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.BMJ open diabetes research & care · 2020Article
- Histone acetyltransferase CBP is critical for conventional effector and memory T-cell differentiation in mice.The Journal of biological chemistry · 2019Article
- Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis.Scientific reports · 2018Article
- Mecp2 regulatesDisease models & mechanisms · 2017Article
- A distal locus element mediates IFN-γ priming of lipopolysaccharide-stimulated TNF gene expression.Cell reports · 2014Article
- Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation.Advances in immunology · 2013Review
- Article
- Monocyte-specific accessibility of a matrix attachment region in the tumor necrosis factor locus.The Journal of biological chemistry · 2011Article
- Arc of a vicious circle: pathways activated by Mycobacterium tuberculosis that target the HIV-1 long terminal repeat.American journal of respiratory cell and molecular biology · 2011Review
- Ordered transcriptional factor recruitment and epigenetic regulation of tnf-alpha in necrotizing acute pancreatitis.Cellular and molecular life sciences : CMLS · 2010Article
- Transcriptional control of the TNF gene.Current directions in autoimmunity · 2010Review
- Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- African swine fever virus blocks the host cell antiviral inflammatory response through a direct inhibition of PKC-theta-mediated p300 transactivation.Journal of virology · 2009Article
- A dimer-specific function of the transcription factor NFATp.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The cAMP response element binding protein (CREB)-binding protein (CBP)/p300 family of coactivator proteins regulates gene transcription through the integration of multiple signal transduction pathways. Here, we show that induction of tumor necrosis factor alpha (TNF-alpha) gene expression in T cells stimulated by engagement of the T cell receptor (TCR) or by virus infection requires CBP/p300. Strikingly, in mice lacking one copy of the CBP gene, TNF-alpha gene induction by TCR activation is inhibited, whereas virus induction of the TNF-alpha gene is not affected. Consistent with these findings, the transcriptional activity of CBP is strongly potentiated by TCR activation but not by virus infection of T cells. Thus, CBP gene dosage and transcriptional activity are critical in TCR-dependent TNF-alpha gene expression, demonstrating a stimulus-specific requirement for CBP in the regulation of a specific gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.