ArticleClinical and experimental immunology2000
Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)-induced arthritis.
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Unique, Specific CART Receptor-Independent Regulatory Mechanism of CART(55-102) Peptide in Spinal Nociceptive Transmission and Its Relation to Dipeptidyl-Peptidase 4 (DDP4).International journal of molecular sciences · 2023Article
- Ameliorated Autoimmune Arthritis and Impaired B Cell Receptor-Mediated CaInternational journal of molecular sciences · 2020Article
- IL-1β Induced Cytokine Expression by Spinal Astrocytes Can Play a Role in the Maintenance of Chronic Inflammatory Pain.Frontiers in physiology · 2020Article
- Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice.Journal of neuroimmunology · 2018Article
- Immunogenicity of recombinant human bocavirus-1,2 VP2 gene virus-like particles in mice.Immunology · 2014Article
- Article
- Commercial bovine proteoglycan is highly arthritogenic and can be used as an alternative antigen source for PGIA model.BioMed research international · 2014Article
- Article
- Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis.Arthritis and rheumatism · 2011Article
- Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis.Immunity & ageing : I & A · 2009Article
- Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice.International immunology · 2009Article
- Development of proteoglycan-induced arthritis is independent of IL-17.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Differential regulation of osteoblast activity by Th cell subsets mediated by parathyroid hormone and IFN-gamma.Journal of immunology (Baltimore, Md. : 1950) · 2005Article
- CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis.Arthritis research & therapy · 2003Article
- Continuous nasal administration of antigen is critical to maintain tolerance in adoptively transferred autoimmune arthritis in SCID mice.Clinical and experimental immunology · 2002Article
- Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis.Arthritis research · 2002Article
- Paradoxical roles of IFN-gamma in models of Th1-mediated autoimmunity.Arthritis research · 2002Review
- Humanized mice as a model for rheumatoid arthritis.Arthritis research · 2002Review
- Anti-inflammatory and chondroprotective effect of TSG-6 (tumor necrosis factor-alpha-stimulated gene-6) in murine models of experimental arthritis.The American journal of pathology · 2001Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The central role of CD4+ T cells and the balance between T helper (Th) subpopulations in the pathogenesis of autoimmune diseases have been extensively studied. Proteoglycan (aggrecan)-induced arthritis (PGIA) is a murine model for rheumatoid arthritis (RA), which is characterized by a Th1 dominance at the onset of the disease. In addition to CD4+ T cells, antigen-presenting B cells and autoantibodies seem to play an important role in the development and regulation of PGIA. To identify proteoglycan-specific CD4+ T cell subsets and Th1- and Th2-supported antibody isotypes during the progression of PGIA, spleen cells of proteoglycan-immunized BALB/c mice were harvested at different times of immunization, and at different stages of the disease, and their cytokine production and antigen-specific antibody isotype profiles were determined by enzyme-linked immunospot (ELISPOT) assays. Both Th1 and Th2 cytokine-producing cells, with the predominance of IL-4/IL-5-secreting cells, were detected during the prearthritic stage, and a shift toward a Th1 dominance was observed at the time of onset of arthritis. Tissue homogenates of acutely inflamed joints contained significantly higher levels of interferon-gamma than IL-4. The prearthritic period and both the acute and chronic phases of joint inflammation were characterized by IgG1 dominance in the sera and this correlated with the number of IgG1-secreting B cells in the spleen. However, the ratio of autoreactive IgG1/IgG2a-secreting cells decreased in arthritic animals. These results indicate the activation and possible regulatory roles of both Th1 and Th2 subsets in the autoimmune process, with the necessity of a relative increase of autoreactive Th1 cells for the induction of joint inflammation.
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