ArticleProceedings of the National Academy of Sciences of the United States of America2000
A causal link between respiration and senescence in Podospora anserina.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 166 citations in OpenAlex.
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- The hyperfunction theory: An emerging paradigm for the biology of aging.Ageing research reviews · 2022Review
- Aging ofCells · 2021Article
- Dynamic Regulation of Peroxisomes and Mitochondria during Fungal Development.Journal of fungi (Basel, Switzerland) · 2020Review
- Distinct Contributions of the Peroxisome-Mitochondria Fission Machinery During Sexual Development of the FungusFrontiers in microbiology · 2020Article
- The Rare Sugar Tagatose Differentially Inhibits the Growth ofFrontiers in microbiology · 2020Article
- Alternative oxidase confers nutritional limitation on Drosophila development.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2019Article
- Alternative Oxidase Transcription Factors AOD2 and AOD5 ofG3 (Bethesda, Md.) · 2017Article
- Regulated Forms of Cell Death in Fungi.Frontiers in microbiology · 2017Review
- Regulation of Aerobic Energy Metabolism in Podospora anserina by Two Paralogous Genes Encoding Structurally Different c-Subunits of ATP Synthase.PLoS genetics · 2016Article
- Article
- RCF1-dependent respiratory supercomplexes are integral for lifespan-maintenance in a fungal ageing model.Scientific reports · 2015Article
- Immunosenescence in monocytes, macrophages, and dendritic cells: lessons learned from the lung and heart.Immunology letters · 2014Review
- Maintaining two mating types: structure of the mating type locus and its role in heterokaryosis in Podospora anserina.Genetics · 2014Article
- The transcription factor BcLTF1 regulates virulence and light responses in the necrotrophic plant pathogen Botrytis cinerea.PLoS genetics · 2014Article
- Genetic and functional investigation of Zn(2)Cys(6) transcription factors RSE2 and RSE3 in Podospora anserina.Eukaryotic cell · 2014Article
- Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts.Antioxidants & redox signaling · 2013Review
- Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification.Chemistry & biology · 2013Article
- dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster.Cell cycle (Georgetown, Tex.) · 2012Article
- Age-related oxidative stress compromises endosomal proteostasis.Cell reports · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Senescence, a progressive degenerative process leading to age-related increase in mortality, is found in most eukaryotes. However, the molecular events underlying aging remain largely unknown. Understanding how longevity is regulated is a fundamental problem. Here we demonstrate that the respiratory function is a key factor that contributes to shortening lifespan of the filamentous fungus Podospora anserina. In this organism, senescence is systematically associated with mitochondrial DNA instabilities. We show that inactivation of the nuclear COX5 gene encoding subunit V of the cytochrome c oxidase complex leads to the exclusive use of the alternative respiratory pathway and to a decrease in production of reactive oxygen species. This inactivation results in a striking increase of longevity associated with stabilization of the mitochondrial chromosome. Moreover, accumulation of several senescence-specific mitochondrial DNA molecules is prevented in this nuclear mutant. These findings provide direct evidence of a causal link between mitochondrial metabolism and longevity in Podospora anserina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.