ArticleProceedings of the National Academy of Sciences of the United States of America2000
Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 100 citations in OpenAlex.
- Large-scale genomic analysis of the domestic dog informs biological discovery.Genome research · 2024Review
- Sarcoma Predisposition in Dogs with a Comparative View to Human Orthologous Disease.Veterinary sciences · 2023Review
- Evaluating the Histologic Grade of Digital Squamous Cell Carcinomas in Dogs and Copy Number Variation of KIT Ligand-A Correlation Study.Veterinary sciences · 2023Article
- A comprehensive review of genomic perspectives of canine diseases as a model to study human disorders.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Review
- Increased risk of cancer in dogs and humans: a consequence of recent extension of lifespan beyond evolutionarily-determined limitations?Aging and cancer · 2022Article
- Dysbiosis in a canine model of human fistulizing Crohn's disease.Gut microbes · 2020Article
- Demographic history, selection and functional diversity of the canine genome.Nature reviews. Genetics · 2017Review
- A monograph proposing the use of canine mammary tumours as a model for the study of hereditary breast cancer susceptibility genes in humans.Veterinary medicine and science · 2017Review
- Analysis of large versus small dogs reveals three genes on the canine X chromosome associated with body weight, muscling and back fat thickness.PLoS genetics · 2017Article
- Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait mapping.Disease models & mechanisms · 2016Article
- Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test.Molecular cancer research : MCR · 2015Article
- Insights into morphology and disease from the dog genome project.Annual review of cell and developmental biology · 2014Review
- A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit.PLoS genetics · 2013Article
- Breed-predispositions to cancer in pedigree dogs.ISRN veterinary science · 2013Article
- Franklin H. Epstein Lecture. Both ends of the leash--the human links to good dogs with bad genes.The New England journal of medicine · 2012Article
- Leading the way: finding genes for neurologic disease in dogs using genome-wide mRNA sequencing.BMC genetics · 2012Article
- Article
- The folliculin mutation database: an online database of mutations associated with Birt-Hogg-Dubé syndrome.Human mutation · 2009Article
- Article
- BHD mutations, clinical and molecular genetic investigations of Birt-Hogg-Dubé syndrome: a new series of 50 families and a review of published reports.Journal of medical genetics · 2008Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a rare, naturally occurring inherited cancer syndrome observed in dogs. Genetic linkage analysis of an RCND-informative pedigree has identified a linkage group flanking RCND (CHP14-C05.377-C05.414-FH2383-C05. 771-[RCND-CPH18]-C02608-GLUT4-TP53-ZuBe Ca6-AHT141-FH2140-FH2594) thus localizing the disease to a small region of canine chromosome 5. The closest marker, C02608, is linked to RCND with a recombination fraction (theta) of 0.016, supported by a logarithm of odds score of 16.7. C02608 and the adjacent linked markers map to a region of the canine genome corresponding to portions of human chromosomes 1p and 17p. A combination of linkage analysis and direct sequencing eliminate several likely candidate genes, including tuberous sclerosis 1 and 2 genes (TSC1 and TSC2) and the tumor suppressor gene TP53. These data suggest that RCND may be caused by a previously unidentified tumor suppressor gene and highlight the potential for canine genetics in the study of human disease predisposition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.