ArticleProceedings of the National Academy of Sciences of the United States of America2000
Evolution of the rodent eosinophil-associated RNase gene family by rapid gene sorting and positive selection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 137 citations in OpenAlex.
- OsRNS4-mediated cross-kingdom RNA interference is inhibited byScience advances · 2026Article
- Ribonucleases of Mice and Men: Unveiling the Roles of the RNase A Superfamily in Host Defence.Journal of immunology research · 2025Review
- Considerations on the evolutionary biology and functions of eosinophils: what the "haeckel"?Journal of leukocyte biology · 2024Review
- Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla.Science China. Life sciences · 2023Article
- Genome-wide identification and expression pattern analysis of the ribonuclease T2 family in Eucommia ulmoides.Scientific reports · 2021Article
- The immune-modulating pregnancy-specific glycoproteins evolve rapidly and their presence correlates with hemochorial placentation in primates.BMC genomics · 2021Article
- Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11.Mucosal immunology · 2021Article
- An ancient evolutionary connection between Ribonuclease A and EndoU families.RNA (New York, N.Y.) · 2020Article
- Contributions of Eosinophils to Human Health and Disease.Annual review of pathology · 2020Review
- Phosphate-Starvation-Inducible S-Like RNase Genes in Rice Are Involved in Phosphate Source Recycling by RNA Decay.Frontiers in plant science · 2020Article
- The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection.Frontiers in immunology · 2019Review
- Evolutionary Trends in RNA Base Selectivity Within the RNase A Superfamily.Frontiers in pharmacology · 2019Article
- The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily.Vaccines · 2018Review
- Alternaria alternata challenge at the nasal mucosa results in eosinophilic inflammation and increased susceptibility to influenza virus infection.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Immune Modulation by Human Secreted RNases at the Extracellular Space.Frontiers in immunology · 2018Review
- The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement.The Biochemical journal · 2016Article
- Developing informative microsatellite markers for non-model species using reference mapping against a model species' genome.Scientific reports · 2016Article
- Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense.International journal of molecular sciences · 2015Review
- Eosinophil-associated ribonuclease 11 is a macrophage chemoattractant.The Journal of biological chemistry · 2015Article
- Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract.Kidney international · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian RNase A superfamily comprises a diverse array of ribonucleolytic proteins that have a variety of biochemical activities and physiological functions. Two rapidly evolving RNases of higher primates are of particular interest as they are major secretory proteins of eosinophilic leukocytes and have been found to possess anti-pathogen activities in vitro. To understand how these RNases acquired this function during evolution and to develop animal models for the study of their functions in vivo, it is necessary to investigate these genes in many species. Here, we report the sequences of 38 functional genes and 23 pseudogenes of the eosinophil-associated RNase (EAR) family from 5 rodent species. Our phylogenetic analysis of these genes showed a clear pattern of evolution by a rapid birth-and-death process and gene sorting, a process characterized by rapid gene duplication and deactivation occurring differentially among lineages. This process ultimately generates distinct or only partially overlapping inventories of the genes, even in closely related species. Positive Darwinian selection also contributed to the diversification of these EAR genes. The striking similarity between the evolutionary patterns of the EAR genes and those of the major histocompatibility complex, immunoglobulin, and T cell receptor genes stands in strong support of the hypothesis that host-defense and generation of diversity are among the primary physiological function of the rodent EARs. The discovery of a large number of divergent EARs suggests the intriguing possibility that these proteins have been specifically tailored to fight against distinct rodent pathogens.
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