ArticleGenetics2000
Adaptive evolution of relish, a Drosophila NF-kappaB/IkappaB protein.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Non-additive transcriptional regulation underpins an additive survival trait in populations of Drosophila selected for increased post infection survival.BMC ecology and evolution · 2026Article
- Predictors of Protein Evolution in the drosophilid Immune System.Genome biology and evolution · 2026Article
- The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes.Genome biology and evolution · 2023Article
- Intermolecular Interactions Drive Protein Adaptive and Coadaptive Evolution at Both Species and Population Levels.Molecular biology and evolution · 2022Article
- Article
- Immune genes and divergent antimicrobial peptides in flies of the subgenus Drosophila.BMC evolutionary biology · 2016Article
- Head Transcriptomes of Two Closely Related Species of Fruit Flies of the Anastrepha fraterculus Group Reveals Divergent Genes in Species with Extensive Gene Flow.G3 (Bethesda, Md.) · 2016Article
- Perspectives on the evolutionary ecology of arthropod antimicrobial peptides.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Evolutionary genetics of insect innate immunity.Briefings in functional genomics · 2015Review
- Population genetics of Anopheles coluzzii immune pathways and genes.G3 (Bethesda, Md.) · 2014Article
- Novel Drosophila viruses encode host-specific suppressors of RNAi.PLoS pathogens · 2014Article
- Population genetic tools for dissecting innate immunity in humans.Nature reviews. Immunology · 2013Review
- Proteolytic activation and function of the cytokine Spätzle in the innate immune response of a lepidopteran insect, Manduca sexta.The FEBS journal · 2010Article
- Quantifying adaptive evolution in the Drosophila immune system.PLoS genetics · 2009Article
- Fine pathogen discrimination within the APL1 gene family protects Anopheles gambiae against human and rodent malaria species.PLoS pathogens · 2009Article
- Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing.BMC genomics · 2009Article
- Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors.Malaria journal · 2009Article
- Recurrent positive selection of the Drosophila hybrid incompatibility gene Hmr.Molecular biology and evolution · 2008Article
- Host ecology shapes geographical variation for resistance to bacterial infection in Drosophila melanogaster.The Journal of animal ecology · 2008Article
- Natural selection on the Drosophila antimicrobial immune system.Current opinion in microbiology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
NF-kappaB and IkappaB proteins have central roles in regulation of inflammation and innate immunity in mammals. Homologues of these proteins also play an important role in regulation of the Drosophila immune response. Here we present a molecular population genetic analysis of Relish, a Drosophila NF-kappaB/IkappaB protein, in Drosophila simulans and D. melanogaster. We find strong evidence for adaptive protein evolution in D. simulans, but not in D. melanogaster. The adaptive evolution appears to be restricted to the IkappaB domain. A possible explanation for these results is that Relish is a site of evolutionary conflict between flies and their microbial pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.