ArticleGenetics2000
Trinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 126 citations in OpenAlex.
- Article
- Genome-wide identification and characterization of functionally relevant microsatellite markers from transcription factor genes of Tea (Camellia sinensis (L.) O. Kuntze).Scientific reports · 2022Article
- Tandem Repeats Contribute to Coding Sequence Variation in Bumblebees (Hymenoptera: Apidae).Genome biology and evolution · 2018Article
- Diverse single-amino-acid repeat profiles in the genus Cryptosporidium.Parasitology · 2018Article
- Biological Roles of Protein-Coding Tandem Repeats in the YeastJournal of fungi (Basel, Switzerland) · 2018Article
- Selection processes in simple sequence repeats suggest a correlation with their genomic location: insights from a fungal model system.BMC genomics · 2015Article
- Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity.Molecular cell · 2015Article
- Development and Characterization of Transcription Factor Gene-Derived Microsatellite (TFGM) Markers in Medicago truncatula and Their Transferability in Leguminous and Non-Leguminous Species.Molecules (Basel, Switzerland) · 2015Article
- Genome-wide analysis of simple sequence repeats in marine animals-a comparative approach.Marine biotechnology (New York, N.Y.) · 2014Article
- Article
- Transcriptome analysis in sheepgrass (Leymus chinensis): a dominant perennial grass of the Eurasian Steppe.PloS one · 2013Article
- Beyond junk-variable tandem repeats as facilitators of rapid evolution of regulatory and coding sequences.Genes · 2012Article
- Article
- Gene discovery in the threatened elkhorn coral: 454 sequencing of the Acropora palmata transcriptome.PloS one · 2011Article
- Predicting genome-wide redundancy using machine learning.BMC evolutionary biology · 2010Article
- Search for informative polymorphisms in candidate genes: clock genes and circadian behaviour in blue tits.Genetica · 2009Article
- Genic non-coding microsatellites in the rice genome: characterization, marker design and use in assessing genetic and evolutionary relationships among domesticated groups.BMC genomics · 2009Article
- Tandem and cryptic amino acid repeats accumulate in disordered regions of proteins.Genome biology · 2009Article
- Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2008Review
- Simple sequence repeats in Neurospora crassa: distribution, polymorphism and evolutionary inference.BMC genomics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The genome of Saccharomyces cerevisiae contains numerous unstable microsatellite sequences. Mononucleotide and dinucleotide repeats are rarely found in ORFs, and when present in an ORF are frequently located in an intron or at the C terminus of the protein, suggesting that their instability is deleterious to gene function. DNA trinucleotide repeats (TNRs) are found at a higher-than-expected frequency within ORFs, and the amino acids encoded by the TNRs represent a biased set. TNRs are rarely conserved between genes with related sequences, suggesting high instability or a recent origin. The genes in which TNRs are most frequently found are related to cellular regulation. The protein structural database is notably lacking in proteins containing amino acid tracts, suggesting that they are not located in structured regions of a protein but are rather located between domains. This conclusion is consistent with the location of amino acid tracts in two protein families. The preferred location of TNRs within the ORFs of genes related to cellular regulation together with their instability suggest that TNRs could have an important role in speciation. Specifically, TNRs could serve as hot spots for recombination leading to domain swapping, or mutation of TNRs could allow rapid evolution of new domains of protein structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.