Trial reportLipids2000
A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers.
Trial report in Lipids, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- The effects of alcohol consumption on flow-mediated dilation in humans: A systematic review.Physiological reports · 2021Pooled it
- Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.International journal of molecular sciences · 2018Pooled it
- Carbohydrate restriction with postmeal walking effectively mitigates postprandial hyperglycemia and improves endothelial function in type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2018Trial
- Effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension.Vascular health and risk management · 2013Trial
- Effects of soy supplementation on blood lipids and arterial function in hypercholesterolaemic subjects.European journal of clinical nutrition · 2005Trial
- Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women.European journal of clinical nutrition · 2003Trial
- Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors.European journal of clinical nutrition · 2001Trial
- Examining the French paradox: a systematic review of red wine consumption and cardiovascular risk.Annals of medicine and surgery (2012) · 2025Article
- Yeast Starter Culture Identification to Produce of Red Wines with Enhanced Antioxidant Content.Foods (Basel, Switzerland) · 2024Article
- The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review.Molecules (Basel, Switzerland) · 2021Review
- Synergistic mechanisms of Sanghuang-Danshen phytochemicals on postprandial vascular dysfunction in healthy subjects: A network biology approach based on a clinical trial.Scientific reports · 2019Article
- Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects.Journal of clinical medicine · 2019Article
- Article
- Is Grassfed Meat and Dairy Better for Human and Environmental Health?Frontiers in nutrition · 2019Article
- Vanillin Alleviates High Fat Diet-Induced Obesity and Improves the Gut Microbiota Composition.Frontiers in microbiology · 2018Article
- Multiple anti-inflammatory and anti-atherosclerotic properties of red wine polyphenolic extracts: differential role of hydroxycinnamic acids, flavonols and stilbenes on endothelial inflammatory gene expression.European journal of nutrition · 2016Article
- Endothelial function, arterial stiffness and adherence to the 2010 Dietary Guidelines for Americans: a cross-sectional analysis.The British journal of nutrition · 2015Article
- Endothelium and its alterations in cardiovascular diseases: life style intervention.BioMed research international · 2014Review
- Mediterranean Diet and Workplace Health Promotion.Current cardiovascular risk reports · 2014Review
- Response to improvement of arterial stiffness in the transition from acute decompensated heart failure to chronic compensated heart failure.Clinical cardiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelial dysfunction is associated with atherogenesis and oxidative stress in humans. In rat and rabbit blood vessels, wine polyphenol antioxidants induce vascular relaxation in vitro through the NO-cGMP pathway. To assess the effect of a regular high-fat diet (HFD) and moderate red wine consumption on endothelial function (EF), a study was performed in healthy male volunteers. EF was measured as flow-mediated dilatation of the brachial artery, employing high-resolution ultrasound after an overnight fast. Other clinical and biochemical parameters related to EF were also measured. Six volunteers received a control diet, rich in fruits and vegetables (27% calories as fat) and five volunteers received an HFD (39.5% calories as fat). Measurements were done twice on each volunteer: after a period of 30 d with diet plus 240 mL of red wine/d, and after a period of 30 d with diet, without wine. In the absence of wine, there is a reduction of EF with HFD when compared to the control diet (P = 0.014). This loss of EF is not seen when both diets are supplemented with wine for 30 d (P = 0.001). Plasma levels of n-3 fatty acids (R2 = 0.232, P = 0.023) and lycopene (R2 = 0.223, P = 0.020) show a positive correlation with individual EF measurements, but they do not account for the significant differences observed among dietary groups or after wine supplementation. These results help elucidate the deleterious effect of a high-fat diet and the protective role of wine, n-3 fatty acids and dietary antioxidants in cardiovascular disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.