ArticleJournal of virology2000
Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 120 citations in OpenAlex.
- Herpes simplex virus type 1 interferes with signal transducer and activator of transcription 3 expression in infected mature dendritic cells.The Journal of general virology · 2026Article
- [Programmed cell death in paramyxovirus infection].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Review
- FAS mediates apoptosis, inflammation, and treatment of pathogen infection.Frontiers in cellular and infection microbiology · 2025Review
- A Morbillivirus Infection Shifts DC Maturation Toward a Tolerogenic Phenotype to Suppress T Cell Activation.Journal of virology · 2022Article
- Innate control of adaptive immunity and adaptive instruction of innate immunity: bi-directional flow of information.Current opinion in immunology · 2021Review
- Japanese Encephalitis Virus NS2B-3 Protein Complex Promotes Cell Apoptosis and Viral Particle Release by Down-Regulating the Expression of AXL.Virologica Sinica · 2021Article
- Newcastle Disease Virus Inhibits the Proliferation of T Cells Induced by Dendritic CellsFrontiers in immunology · 2020Article
- Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium.Frontiers in immunology · 2019Article
- TLR2/MyD88 pathway-dependent regulation of dendritic cells by dengue virus promotes antibody-dependent enhancement via Th2-biased immunity.Oncotarget · 2017Article
- Does Zika virus infection induce prolonged remissions in children with idiopathic nephrotic syndrome?Pediatric nephrology (Berlin, Germany) · 2017Article
- The influence of infectious factors on dendritic cell apoptosis.Archives of medical science : AMS · 2015Article
- Immune-mediated Liver Injury in Hepatitis B Virus Infection.Immune network · 2015Review
- Article
- Measles immune suppression: functional impairment or numbers game?PLoS pathogens · 2014Article
- Loss of the death receptor CD95 (Fas) expression by dendritic cells protects from a chronic viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Dendritic cell apoptosis and the pathogenesis of dengue.Viruses · 2012Review
- Engineered measles virus Edmonston strain used as a novel oncolytic viral system against human hepatoblastoma.BMC cancer · 2012Article
- A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes.Journal of virology · 2012Article
- Protective potential of MMR vaccine against complete Freund's adjuvant-induced inflammation in rats.Inflammopharmacology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mortality from measles virus (MV) infection is caused mostly by secondary infections associated with a pronounced immunosuppression. Dendritic cells (DCs) represent a major target of MV and could be involved in immunosuppression. In this study, human monocyte-derived DCs were used to demonstrate that DC apoptosis in MV-infected DC-T-cell cocultures is Fas mediated, whereas apoptotic T cells could not be rescued by blocking the Fas pathway. Two novel consequences of DC apoptosis after MV infection were demonstrated. (i) Fas-mediated apoptosis of DCs facilitates MV release, while CD40 activation enhances MV replication in DCs. Indeed, detailed studies of infectious MV release and intracellular MV nucleoprotein (NP) showed that inhibition of CD40-CD40L ligand interaction blocks NP synthesis. We conclude that the CD40 ligand expressed by activated T cells first enhances MV replication in DCs, and then Fas ligand produced by activated T cells induces Fas-mediated apoptosis of DCs, thus facilitating MV release. (ii) Not only MV-infected DCs but also bystander uninfected DCs undergo a maturation process confirmed by CD1a, CD40, CD80, CD86, CD83, and major histocompatibility complex type II labeling. The bystander maturation effect results from contact and/or engulfment of MV-induced apoptotic DCs by uninfected DCs. A model is proposed to explain how both a specific immune response and immunosuppression can simultaneously occur after MV infection through Fas-mediated apoptosis and CD40 activation of DCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.