ArticleJournal of virology2000
Dominant role of host selective pressure in driving hepatitis C virus evolution in perinatal infection.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Species-specific barriers restrict virus spillover potential across the Caenorhabditis genus.PLoS biology · 2026Article
- Detection of low-level HCV variants in DAA treated patients: comparison amongst three different NGS data analysis protocols.Virology journal · 2020Article
- Vertical Transmission of Hepatitis C Virus: Variable Transmission Bottleneck and Evidence of MidgestationJournal of virology · 2017Article
- Vertically acquired hepatitis C virus infection: Correlates of transmission and disease progression.World journal of gastroenterology · 2016Review
- Hepatitis C virus genetic variability and evolution.World journal of hepatology · 2015Review
- Hepatitis C virus adaptation to T-cell immune pressure.TheScientificWorldJournal · 2013Review
- Birds shed RNA-viruses according to the pareto principle.PloS one · 2013Article
- Review
- Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host.Journal of virology · 2012Article
- Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission.Journal of clinical microbiology · 2012Article
- Phylogeny and phylodinamic of Hepatitis C in Italy.BMC infectious diseases · 2012Review
- Effect of immune pressure on hepatitis C virus evolution: insights from a single-source outbreak.Hepatology (Baltimore, Md.) · 2011Article
- Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity.World journal of gastroenterology · 2010Article
- Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes.PloS one · 2009Article
- Analysis of the overdispersed clock in the short-term evolution of hepatitis C virus: Using the E1/E2 gene sequences to infer infection dates in a single source outbreak.Molecular biology and evolution · 2006Article
- Evolution of hepatitis C viral quasispecies and hepatic injury in perinatally infected children followed prospectively.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Effect of bottlenecking on evolution of the nonstructural protein 3 gene of hepatitis C virus during sexually transmitted acute resolving infection.Journal of virology · 2005Article
- Vertical transmission of the hepatitis C virus to infants of anti-human immunodeficiency virus-negative mothers: molecular evolution of hypervariable region 1 in prenatal and perinatal or postnatal infections.Journal of clinical microbiology · 2003Article
- Managing occupational risks for hepatitis C transmission in the health care setting.Clinical microbiology reviews · 2003Review
- Mapping B-cell epitopes of hepatitis C virus E2 glycoprotein using human monoclonal antibodies from phage display libraries.Journal of virology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dynamics of the genetic diversification of hepatitis C virus (HCV) populations was addressed in perinatal infection. Clonal sequences of hypervariable region 1 of the putative E2 envelope protein of HCV were obtained from four HCV-infected newborns (sequential samples spanning a period of 6 to 13 months after birth) and from their mothers (all samples collected at delivery). The data show that the variants detected between birth and the third month of life in samples from the four newborns were present in the HCV populations of their mothers at delivery. In the newborns, a unique viral variant (or a small group of closely related variants) remained stable for weeks despite active viral replication. Diversification of the intrahost HCV population was observed 6 to 13 months after birth and was substantially higher in two of the four subjects, as documented by the intersample genetic distance (GD) (P = 0.007). Importantly, a significant correlation between increasing GD and high values for the intersample K(a)/K(s) ratio (the ratio between anoffymous and synonymous substitutions; an index of the action of selective forces) was observed, as documented by the increase of both parameters over time (P = 0.01). These data argue for a dominant role of positive selection for amino acid changes in driving the pattern of genetic diversification of HCV populations, indicate that the intrahost evolution of HCV populations is compatible with a Darwinian model system, and may have implications in the designing of future antiviral strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.