ArticleJournal of virology2000
Protection of the villus epithelial cells of the small intestine from rotavirus infection does not require immunoglobulin A.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 76 citations in OpenAlex.
- Study of the Ability of Bifidobacteria of Human Origin to Prevent and Treat Rotavirus Infection Using Colonic Cell and Mouse Models.PloS one · 2016Article
- Protection against live rotavirus challenge in mice induced by parenteral and mucosal delivery of VP6 subunit rotavirus vaccine.Archives of virology · 2015Article
- Mutations in toll-like receptor 3 are associated with elevated levels of rotavirus-specific IgG antibodies in IgA-deficient but not IgA-sufficient individuals.Clinical and vaccine immunology : CVI · 2014Article
- Plasmacytoid dendritic cells promote rotavirus-induced human and murine B cell responses.The Journal of clinical investigation · 2013Article
- IgA is important for clearance and critical for protection from rotavirus infection.Mucosal immunology · 2012Article
- HSV-1 amplicon vectors launch the production of heterologous rotavirus-like particles and induce rotavirus-specific immune responses in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- Inhibitory effects of bile acids and synthetic farnesoid X receptor agonists on rotavirus replication.Journal of virology · 2011Article
- The role of secretory antibodies in infection immunity.Nature reviews. Microbiology · 2010Review
- Antibody is critical for the clearance of murine norovirus infection.Journal of virology · 2008Article
- Differential requirements for T cells in viruslike particle- and rotavirus-induced protective immunity.Journal of virology · 2008Article
- Role of interleukin-4 (IL-4) and IL-10 in serum immunoglobulin G antibody responses following mucosal or systemic reovirus infection.Journal of virology · 2004Article
- Fecal immunoglobulin A antibodies in dogs infected or vaccinated with canine coronavirus.Clinical and diagnostic laboratory immunology · 2004Article
- Secretory immunoglobulin A antibodies against the sigma1 outer capsid protein of reovirus type 1 Lang prevent infection of mouse Peyer's patches.Journal of virology · 2004Article
- Secretory antibodies do not affect the composition of the bacterial microbiota in the terminal ileum of 10-week-old mice.Applied and environmental microbiology · 2003Article
- Induction of mucosal immune responses and protection against enteric viruses: rotavirus infection of gnotobiotic pigs as a model.Veterinary immunology and immunopathology · 2002Review
- Heterologous protection induced by the inner capsid proteins of rotavirus requires transcytosis of mucosal immunoglobulins.Journal of virology · 2002Article
- Role of immunoglobulin A in protection against reovirus entry into Murine Peyer's patches.Journal of virology · 2001Article
- B2 but not B1 cells can contribute to CD4+ T-cell-mediated clearance of rotavirus in SCID mice.Journal of virology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin A (IgA) is the primary immune response induced in the intestine by rotavirus infection, but vaccination with virus-like particles induces predominantly IgG, not IgA. To definitively assess the role of IgA in protection from rotavirus infection, IgA knockout mice, which are devoid of serum and secretory IgA, were infected and then rechallenged with murine rotavirus at either 6 weeks or 10 months. Following primary rotavirus infection, IgA knockout mice cleared virus as effectively as IgA normal control mice. Rotavirus-infected IgA knockout mice produced no serum or fecal IgA but did have high levels of antirotavirus serum IgG and IgM and fecal IgG, whereas IgA normal control mice made both serum IgA and IgG and fecal IgA. Both IgA normal and IgA knockout mice were totally protected from rotavirus challenge at 42 days. Ten months following a primary infection, both IgA normal and knockout mice still had high levels of serum and fecal antirotavirus antibody and were totally protected from rotavirus challenge. To determine if compensatory mechanisms other than IgG were responsible for protection from rotavirus infection in IgA knockout mice, mice were depleted of CD4(+) T cells or CD8(+) T cells. No changes in the level of protection were seen in depleted mice. These data show that fecal or systemic IgA is not essential for protection from rotavirus infection and suggest that in the absence of IgA, IgG may play a significant role in protection from mucosal pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.