ArticleThe Journal of experimental medicine2000
Identical T cell clones are located within the mouse gut epithelium and lamina propia and circulate in the thoracic duct lymph.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 104 citations in OpenAlex.
- Dietary antigens drive the generation of functional cytotoxic intraepithelial lymphocytes for early defense against foodborne pathogens.Frontiers in immunology · 2025Article
- Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024Review
- Myeloid Cell-Derived IL-1 Signaling Damps Neuregulin-1 from Fibroblasts to Suppress Colitis-Induced Early Repair of the Intestinal Epithelium.International journal of molecular sciences · 2024Article
- The interaction between intestinal microenvironment and stroke.CNS neuroscience & therapeutics · 2023Review
- Human intraepithelial lymphocytes.Mucosal immunology · 2018Review
- Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing TNature immunology · 2018Article
- Tissue adaptation: Implications for gut immunity and tolerance.The Journal of experimental medicine · 2017Review
- Amelioration of experimental colitis after short-term therapy with glucocorticoid and its relationship to the induction of different regulatory markers.Immunology · 2017Article
- CD8αα TCRαβ Intraepithelial Lymphocytes in the Mouse Gut.Digestive diseases and sciences · 2016Review
- Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis.Mediators of inflammation · 2016Article
- Mucosal-associated invariant T cell-rich congenic mouse strain allows functional evaluation.The Journal of clinical investigation · 2015Article
- MAIT cells are depleted early but retain functional cytokine expression in HIV infection.Immunology and cell biology · 2015Article
- The Interaction among Microbiota, Immunity, and Genetic and Dietary Factors Is the Condicio Sine Qua Non Celiac Disease Can Develop.Journal of immunology research · 2015Review
- GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.The Journal of experimental medicine · 2014Article
- The unique surface molecules on intestinal intraepithelial lymphocytes: from tethering to recognizing.Digestive diseases and sciences · 2014Review
- Use of gnotobiotic mice to identify and characterize key microbes responsible for the development of the intestinal immune system.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2014Review
- Origin, trafficking, and intraepithelial fate of gut-tropic T cells.The Journal of experimental medicine · 2013Article
- Article
- Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.European journal of microbiology & immunology · 2012Article
- Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Murine gut intraepithelial (IEL) T cell receptor (TCR)-alpha/beta lymphocytes bearing CD8alpha/13 or CD8alpha/alpha coreceptors have been shown previously to express different oligoclonal TCR beta chain repertoires in the same mouse, in agreement with other evidence indicating that these two populations belong to different ontogenic lineages, with only CD8alpha/beta+ IELs being fully thymus dependent. CD8alpha/beta+, but not CD8alpha/alpha+, T lymphocytes are also present in the lamina propria. Here, we show that CD8alpha/beta+ lymphocytes from the lamina propria and the epithelium are both oligoclonal, and that they share the same TCR-beta clonotypes in the same mouse, as is also the case for CD4alpha T cells. Furthermore, identical T cell clones were detected among CD8alpha/beta IELs and CD8alpha/beta+ blasts circulating into the thoracic duct (TD) lymph of the same mouse, whereas TD small lymphocytes are polyclonal. These findings must be considered in light of previous observations showing that T blasts, but not small T lymphocytes, circulating in the TD lymph have the capacity of homing into the gut epithelium and lamina propria. These combined observations have interesting implications for our understanding of the recirculation of gut thymus-dependent lymphocytes and their precursors, and of the events leading up to the selection of their restricted TCR repertoire.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.