ArticleBritish journal of cancer2000
Cancer among children of parents with autoimmune diseases.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Application of an obstetric comorbidity index to predict childhood cancer risk: a population based case-control study in Denmark.British journal of cancer · 2025Article
- Maternal autoimmune disease and offspring risk of haematological malignancies: a case-control study.EClinicalMedicine · 2024Article
- Maternal autoimmune disease and its association with childhood cancer: A population-based case-control study in Denmark.EJC paediatric oncology · 2024Article
- Article
- Maternal autoimmune disease is not associated with cancer in the offspring.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
- Acute lymphoblastic leukemia in a 2-year-old girl whose mother was previously diagnosed with antiphospholipid syndrome: a case report.BMC research notes · 2015Article
- Infectious, autoimmune and allergic diseases and risk of Hodgkin lymphoma in children and adolescents: a Children's Oncology Group study.International journal of cancer · 2014Article
- Family history of cancer and non-malignant diseases and risk of childhood acute lymphoblastic leukemia: a Children's Oncology Group Study.Cancer epidemiology · 2012Article
- Survival patterns in patients with Hodgkin's lymphoma with a pre-existing hospital discharge diagnosis of autoimmune disease.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2010Article
- Genetic susceptibility to childhood leukaemia.Radiation protection dosimetry · 2008Review
- Malignancy and rheumatoid arthritis.Current rheumatology reports · 2007Review
- Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries.Blood · 2006Article
- Childhood malignancy and maternal diabetes or other auto-immune disease during pregnancy.British journal of cancer · 2002Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many different aetiologies for childhood cancer have been suggested, but few are well established. One is that parental autoimmune disease is linked with susceptibility for haematopoietic malignancies in their offspring during childhood. The present study is the first to investigate this hypothesis using a follow-up design. A cohort of 53,811 children of more than 36,000 patients diagnosed with a systemic, organ-specific or suspected autoimmune disease were followed up for cancer incidence in the Danish Cancer Registry during 1968-1993. The parents were identified through the National Registry of Patients, while their children were traced in the Central Population Register. Cancer incidence among the offspring was compared with that in the corresponding childhood population of Denmark. In total, 115 cancers were observed among children aged 0-19 years, yielding a non-significant standardized incidence ratio of 1.07. Lymphomas contributed 21 cases to the overall number of tumours, 60% more than expected (95% confidence interval (CI) 1.0-2.4); leukaemia contributed 37 cases representing an excess of 30% (95% CI 0.9-1.8). Our results give some support to the hypothesis that parental autoimmune disease is associated with childhood lymphoma and leukaemia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.