ArticleBritish journal of cancer2000
The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 86 citations in OpenAlex.
- Ileocecal Lipoma as a Lead Point for Adult Ileocolic Intussusception: A Diagnostic Challenge.Case reports in surgery · 2026Article
- Molecular feature-based classification of retroperitoneal liposarcoma: a prospective cohort study.eLife · 2025Observational
- HER3 (ERBB3) amplification in liposarcoma - a putative new therapeutic target?World journal of surgical oncology · 2024Article
- FISH Diagnostic Assessment ofInternational journal of molecular sciences · 2023Article
- Glomus Tumor of the Lower Extremity Previously Misdiagnosed as Complex Regional Pain Syndrome in Close Proximity to a Myxofibrosarcoma: A Case Report.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Article
- Expression of FRS2 in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: an immunohistochemical analysis of 182 cases with genetic data.Diagnostic pathology · 2021Article
- Recent Advancement in Atypical Lipomatous Tumor Research.International journal of molecular sciences · 2021Review
- Lipomas of the Oral Cavity: Utility of MDM2 and CDK4 in Avoiding Overdiagnosis as Atypical Lipomatous Tumor.Head and neck pathology · 2019Article
- Primary endobronchial liposarcoma successfully resected via bronchoscopy: A rare case report with genetic analysis.Oncology letters · 2018Article
- Paratesticular liposarcoma and contralateral angiolipoma in a 60-year-old patient.BMJ case reports · 2015Article
- [Molecular pathology of soft tissue tumors: Contribution to diagnosis and therapy prediction].Der Pathologe · 2015Review
- Article
- Cyclin-dependent kinase 4 overexpression is mostly independent of gene amplification and constitutes an independent prognosticator for nasopharyngeal carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Article
- CDK4 amplification predicts recurrence of well-differentiated liposarcoma of the abdomen.PloS one · 2014Article
- Can HMGI-C be used as an aid with MDM2 and CDK4 to differentiate liposarcoma subtypes from their mimics?Journal of cancer research and clinical oncology · 2013Article
- Utility of fluorescence in situ hybridization to detect MDM2 amplification in liposarcomas and their morphological mimics.International journal of clinical and experimental pathology · 2013Article
- Well-differentiated and dedifferentiated liposarcomas.Virchows Archiv : an international journal of pathology · 2010Review
- Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.Nature reviews. Cancer · 2006Review
- Focal lymphoid hyperplasia in a lipoma, mimicking liposarcoma.Skeletal radiology · 2006Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12q13-15, whereas well differentiated liposarcomas (WDL) show supernumerary ring and giant marker chromosomes, known to contain amplified 12q sequences. The tight correlation between the presence of ring chromosomes and both amplification and overexpression of MDM2 and CDK4 genes suggests the exploration of the possibility that immunocytochemistry (ICC) might assist in the differential diagnosis of lipoma-like well differentiated liposarcomas (LL-WDL) and large deep-seated lipomas (LDSL). For this purpose, 21 cases of the former and 19 cases of the latter tumours were analysed by ICC and, according to the availability of material, by molecular and cytogenetic approaches. All lipomas displayed a null MDM2/CDK4 phenotype, whereas all LL-WDL showed MDM2/CDK4 or CDK4 phenotypes. Southern blot analysis performed on 16 suitable cases, complemented by fluorescence in situ hybridization and classical cytogenetic analysis in 11 cases, was consistent with, and further supported the immunophenotyping data. In conclusion, MDM2/CDK4 product-based immunophenotyping appears to represent a valuable method for the categorization of arguable LDSL.
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