ArticleJournal of assisted reproduction and genetics2000
The effects of age and abnormal sperm count on the nondisjunction of spermatozoa.
Article in Journal of assisted reproduction and genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Fertility in the aging male: a systematic review.Fertility and sterility · 2022Pooled it
- Influence of parental age on chromosomal abnormalities in PGT-A embryos: exponentially increasing in the mother and completely null in the father.Journal of assisted reproduction and genetics · 2025Article
- Y chromosome AZFc microdeletion may have negative effect on embryo euploidy: a retrospective cohort study.BMC medical genomics · 2023Article
- External and Genetic Conditions Determining Male Infertility.International journal of molecular sciences · 2020Review
- Intracytoplasmic sperm injection: state of the art in humans.Reproduction (Cambridge, England) · 2017Review
- Assessment of numerical chromosomal abnormalities of the sperms before and after radiotherapy in seminoma patient.International journal of clinical and experimental medicine · 2014Article
- The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population.Journal of assisted reproduction and genetics · 2011Article
- Sperm rates of 7q11.23, 15q11q13 and 22q11.2 deletions and duplications: a FISH approach.Human genetics · 2011Article
- Scoring of sperm chromosomal abnormalities by manual and automated approaches: qualitative and quantitative comparisons.Asian journal of andrology · 2010Article
- Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- The association between male infertility and sperm disomy: evidence for variation in disomy levels among individuals and a correlation between particular semen parameters and disomy of specific chromosome pairs.Reproductive biology and endocrinology : RB&E · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe effect of paternal age on the nondisjunction of sex chromosomes is controversial. Also, the prevalence of chromosomal anomalies in infertile patients is controversial, it has been reported that the sex chromosomal aneuploidy rate following treatment with intracytoplasmic sperm injection (ICSI) is higher than in naturally conceived pregnancies. We investigated the influence of paternal age and oligozoospermia on the nondisjunction of spermatozoa.
methodsWe determined the rate of aneuploidy for gonosomes and autosomes, using two-color fluorescence in situ hybridization (FISH) of the X and Y chromosomes and chromosomes 12 and 18 in 10 donors under 25 years of age who had a normal sperm count (> or = 20 x 10(6)/ml), 10 donors over the age of 39 years with idiopathic infertility and normozoospermia (> or = 20 x 10(6)/ml), and 5 oligozoospermic donors (< 20 x 10(6)/ml).
resultsThere was no obvious relationship between increasing age and autosomal disomy (disomy 12 and disomy 18). Neither autosomal disomy nor diploidy was increased in any group. The frequency of X-, Y-, XX-, and YY-bearing sperm did not differ significantly among groups, but the frequency of XY-bearing sperm was significantly higher in the older infertile group than in the control donors.
conclusionsThe incidence of nondisjunction of paternal sex chromosome in meiosis I was higher in older men with idiopathic infertility. The present results suggest that the risk of producing XXY fetuses is higher among men > 39 years of age with idiopathic infertility.
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