ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
P2Y(1) purinoceptor-mediated Ca(2+) signaling and Ca(2+) wave propagation in dorsal spinal cord astrocytes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 195 citations in OpenAlex.
- Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats.Experimental neurology · 2012Pooled it
- The Multifaceted Role of P2X7R in Microglia and Astrocytes.Neurochemical research · 2025Review
- The Role of ATP Receptors in Pain Signaling.Neurochemical research · 2022Review
- Glial Purinergic Signaling in Neurodegeneration.Frontiers in neurology · 2021Review
- The Neurobiology of Bipolar Disorder.Current topics in behavioral neurosciences · 2021Article
- Fast and Efficient Differentiation of Mouse Embryonic Stem Cells Into ATP-Responsive Astrocytes.Frontiers in cellular neuroscience · 2019Article
- Physiology of Astroglia.Advances in experimental medicine and biology · 2019Review
- Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential.Nature reviews. Neuroscience · 2018 · on this mapReview
- Modulation of Pain and Itch by Spinal Glia.Neuroscience bulletin · 2018Review
- Activity-induced CaeLife · 2018Article
- Multiple Lines of Evidence Indicate That Gliotransmission Does Not Occur under Physiological Conditions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Ligand binding to a G protein-coupled receptor captured in a mass spectrometer.Science advances · 2017Article
- Extracellular ATP and other nucleotides-ubiquitous triggers of intercellular messenger release.Purinergic signalling · 2016Review
- Enteric glia mediate neuron death in colitis through purinergic pathways that require connexin-43 and nitric oxide.Cellular and molecular gastroenterology and hepatology · 2016Article
- Article
- The regulation of Sox2 and Sox9 stimulated by ATP in spinal cord astrocytes.Journal of molecular neuroscience : MN · 2015Article
- The purinergic neurotransmitter revisited: a single substance or multiple players?Pharmacology & therapeutics · 2014Review
- Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia.Molecular pain · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ATP is known to act as an extracellular messenger mediating the propagation of Ca(2+) waves in astrocyte networks. ATP mediates Ca(2+) waves by activating P2Y purinoceptors, which mobilize intracellular Ca(2+) in astrocytes. A number of P2Y purinoceptor subtypes have been discovered, but it is not known which P2Y subtypes participate in transmitting astrocyte Ca(2+) waves. Here, we show that ATP analogs that are selective agonists for the P2Y(1) subtype of purinoceptor caused release of intracellular Ca(2+) in astrocytes from the dorsal spinal cord. The Ca(2+) responses were blocked by adenosine-3'-phospho-5'-phosphosulfate, an antagonist known to selectively inhibit P2Y(1) but not other P2Y purinoceptor subtypes. Also, we show that P2Y(1) mRNA is expressed in dorsal spinal cord astrocytes. Furthermore, expression of P2Y(1) in an astrocytoma cell line lacking endogenous purinoceptors was sufficient to permit propagation of intercellular Ca(2+) waves. Finally, Ca(2+) wave propagation in dorsal spinal cord astrocytes was suppressed by pharmacologically blocking P2Y(1) purinoceptors. Together, these results indicate that dorsal spinal astrocytes express functional P2Y(1) purinoceptors, which participate in the transmission of Ca(2+) waves. Ca(2+) waves in astrocytes have been implicated as a major signaling pathway coordinating glial and neuronal activity; therefore, P2Y(1) purinoceptors may represent an important link in cell-cell signaling in the CNS.
Indexed as
Identifiers
10751431PMC6772222W2127361742What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.