ArticleThe American journal of pathology2000
Biomaterial-induced sarcoma: A novel model to study preneoplastic change.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 124 citations in OpenAlex.
- A Metal-Associated Epithelioid Angiosarcoma: A Case Report and Literature Review.Hawai'i journal of health & social welfare · 2026Review
- Orthopaedic Implant-Associated Rhabdomyosarcoma.The Journal of the American Academy of Orthopaedic Surgeons · 2025Article
- Cutaneous histiocytic sarcoma arising from soft tissue filler injections: a case report.Frontiers in oncology · 2025Article
- A Novel Rat Model to Simulate Positive Margins in the Wound Bed of a Resected Sarcoma.Plastic and reconstructive surgery. Global open · 2024Article
- Undifferentiated Pleomorphic Sarcoma Mimicking Breast Implant-Associated Anaplastic Large Cell Lymphoma.Journal of breast cancer · 2024Article
- An Update on Implant-Associated Malignancies and Their Biocompatibility.International journal of molecular sciences · 2024Review
- Indications for the removal of implants after fracture healing: A comparison between human and veterinary medicine.Veterinarni medicina · 2023Review
- High-grade pleomorphic sarcoma associated with an orthopedic implant: a rare case report.Oxford medical case reports · 2023Article
- Resorbable MgMaterials (Basel, Switzerland) · 2021Review
- Extraskeletal osteosarcoma misdiagnosed as heterotopic ossification after periprosthetic femoral fracture: A case report.Acta orthopaedica et traumatologica turcica · 2020Article
- Carcinogenic potential of polypropylene mid-urethral slings: what do we know so far?International urogynecology journal · 2017Review
- Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds.Head & neck · 2016Article
- Spontaneous cutaneous soft tissue sarcoma with differentiation into fibroblasts in a Sprague-Dawley rat.Journal of toxicologic pathology · 2016Article
- Total hip arthroplasty-related osteogenic osteosarcoma: case report and review of the literature.European journal of medical research · 2016Review
- Differential Contribution of Acute and Chronic Inflammation to the Development of Murine Mammary 4T1 Tumors.PloS one · 2015Article
- Article
- Polypropylene mesh: evidence for lack of carcinogenicity.International urogynecology journal · 2014Article
- Carcinogenicity of implantable materials: experimental and epidemiological evidence.International urogynecology journal · 2014Article
- Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle and mesothelium.Journal of toxicologic pathology · 2013Review
- Corrosion at the cone/taper interface leads to failure of large-diameter metal-on-metal total hip arthroplasties.Clinical orthopaedics and related research · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the study of carcinogenesis most interest has focused on carcinomas, as they represent the majority of human cancers. The recognition of the adenoma-carcinoma sequence both in humans and in animal experimental models has given the field of basic oncology the opportunity to elucidate individual mechanisms in the multistep development of carcinoma. The relative scarcity of human sarcomas coupled with the lack of adequate animal models has hampered understanding of the molecular genetic steps involved. We present an experimental model in the rat in which a high incidence of malignant mesenchymal tumors arise around a subcutaneously implanted biomaterial. Nine commercially available biomaterials were implanted in a total of 490 rats of the Fischer strain for 2 years. On average, macroscopic tumors were found in 25.8% of implantation sites over a period from 26 to 110 weeks after implantation. The most frequent tumors were malignant fibrous histiocytomas and pleomorphic sarcomas, although fibrosarcomas, leiomyosarcomas, and angiosarcomas readily developed, the latter especially around polyurethane implants. Of particular interest are the results of a detailed histological study of the capsules around the implanted biomaterials without tumors. Here a spectrum of change from focal proliferative lesions through preneoplastic proliferation to incipient sarcoma could be observed. A parallel immunohistochemical study of peri-implant capsules showed that proliferating cell nuclear antigen was of particular help in identifying these atypical proliferative lesions. To our knowledge this is the first description of a sarcoma model in which preneoplastic lesions can be readily identified and also reproducibly induced. This model provides the molecular biologist with defined stages in the development of mesenchymal malignancy, with which the multistage tumorigenesis hypothesis can be tested, analogous to the well-known adenoma-carcinoma sequence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.