ArticleThe American journal of pathology2000
Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Extra-skeletal intracranial mesenchymal chondrosarcoma: systematic-literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Pooled it
- Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma.Laboratory investigation; a journal of technical methods and pathology · 2022Article
- CT and MRI findings of intracranial extraskeletal mesenchymal chondrosarcoma-a case report and literature review.Translational cancer research · 2022Article
- Genomic profiling identifies genes and pathways dysregulated by HEY1-NCOA2 fusion and shines a light on mesenchymal chondrosarcoma tumorigenesis.The Journal of pathology · 2022Article
- Case Report: Primary Intraosseous Poorly Differentiated Synovial Sarcoma of the Femur.Frontiers in oncology · 2022Article
- Chondrosarcoma with undifferentiated neoplastic cell proliferation around the distal tibiotarsus bone in a wild Hooded Crane (Grus monacha).The Journal of veterinary medical science · 2020Article
- Mesenchymal Chondrosarcoma of the Brain with Metastasis: A Case Report with Literature Review.Journal of neurosciences in rural practice · 2020Article
- Article
- Poly(γ-Glutamic Acid) as an Exogenous Promoter of Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells.Tissue engineering. Part A · 2015Article
- The multifaceted role of the vasculature in endochondral fracture repair.Frontiers in endocrinology · 2015Review
- Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Mesenchymal chondrosarcoma of the cervical spine: A case report.The Australasian medical journal · 2011Article
- Actin and Vimentin proteins with N-terminal deletion detected in tumor-bearing rat livers induced by intraportal-vein injection of Ha-ras-transfected rat liver cells.International journal of cancer · 2009Article
- Association between crystals and cartilage degeneration in the ankle.The Journal of rheumatology · 2008Article
- Extraskeletal intracranial mesenchymal chondrosarcoma: case report and literature review.The Kaohsiung journal of medical sciences · 2004Review
- Chondrosarcoma cell differentiation.Pathology oncology research : POR · 2004Article
- Intracranial mesenchymal chondrosarcoma with osteoid formation: report of a pediatric case.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2003Article
- Chondroma of epithelial cell origin.The American journal of pathology · 2003Article
- Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations.The American journal of pathology · 2002Article
- Matrix gene expression analysis and cellular phenotyping in chordoma reveals focal differentiation pattern of neoplastic cells mimicking nucleus pulposus development.The American journal of pathology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesenchymal chondrosarcomas are small-cell malignancies named as chondrosarcomas due to the focal appearance of cartilage islands. In this study, the use of in situ detection techniques on a large series of mesenchymal chondrosarcoma specimens allowed the identification of tumor-cell differentiation pathways in these neoplasms. We were able to trace all steps of chondrogenesis within mesenchymal chondrosarcoma by using characteristic marker genes of chondrocytic development. Starting from undifferentiated cells, which were negative for vimentin and any other mesenchymal marker, a substantial portion of the cellular (undifferentiated) tumor areas showed a chondroprogenitor phenotype with an onset of expression of vimentin and collagen type IIA. Cells in the chondroid areas showed the full expression panel of mature chondrocytes including type X collagen indicating focal hypertrophic differentiation of the neoplastic chondrocytes. Finally, evidence was found for transdifferentiation of the neoplastic chondrocytes to osteoblast-like cells in areas of neoplastic bone formation. These results establish mesenchymal chondrosarcoma as the very neoplasm of differentiating premesenchymal chondroprogenitor cells. The potential of neoplastic bone formation in mesenchymal chondrosarcoma introduces a new concept of neoplastic (chondrocytic) osteogenesis in musculoskeletal malignant neoplasms, which qualifies the old dogma that neoplastic bone/osteoid formation automatically implies the diagnosis of osteosarcoma.
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